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arg11 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543391, updated on 18-Sep-2024

Summary

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Official Symbol
arg11
Official Full Name
N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase
Primary source
PomBase:SPAC4G9.09c
Locus tag
SPOM_SPAC4G9.09C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See arg11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2269908..2272724, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase III complex subunit Rpc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ornithine carbamoyltransferase Arg3 Neighboring gene cytosine-mismatch-binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of arg3 and arg11 genes of Schizosaccharomyces pombe on a 10-kb DNA fragment. Heterologous expression and mitochondrial targeting of their translation products. Van Huffel C, et al. Eur J Biochem, 1992 Apr 1. PMID 1313366
  2. Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast. Malecki M, et al. EMBO Rep, 2020 Nov 5. PMID 32896087, Free PMC Article
  3. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
  4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
  5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables acetylglutamate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine biosynthetic process via ornithine EXP
Inferred from Experiment
more info
 PubMed 
involved_in arginine biosynthetic process via ornithine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2269908..2272724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019123.3 → NP_593691.1  N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593691.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P31318
    Conserved Domains (6) summary
    PRK04531
    Location:60 → 489
    PRK04531; acetylglutamate kinase; Provisional
    cd04252
    Location:94 → 342
    AAK_NAGK-fArgBP; AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal ...
    TIGR01850
    Location:572 → 882
    argC; N-acetyl-gamma-glutamyl-phosphate reductase, common form
    pfam01118
    Location:575 → 695
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain
    pfam04768
    Location:327 → 494
    NAT; NAT, N-acetyltransferase, of N-acetylglutamate synthase
    cl19935
    Location:712 → 860
    Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Nucleotide Protein
Heading Accession and Version

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