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gls2 glucosidase II alpha subunit Gls2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543277, updated on 18-Sep-2024

Summary

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Official Symbol
gls2
Official Full Name
glucosidase II alpha subunit Gls2
Primary source
PomBase:SPAC1002.03c
Locus tag
SPOM_SPAC1002.03C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See gls2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1799915..1803070, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene nucleoporin Pom34 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIID complex subunit Taf11 Neighboring gene histone demethylase Jmj2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate recognition of the catalytic α-subunit of glucosidase II from Schizosaccharomyces pombe. Okuyama M, et al. Biosci Biotechnol Biochem, 2017 Aug. PMID 28471318
  2. Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. Olson LJ, et al. Biochemistry, 2015 Jul 7. PMID 26062005, Free PMC Article
  3. Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo. Stigliano ID, et al. Mol Biol Cell, 2011 Jun 1. PMID 21471007, Free PMC Article
  4. Glucosidase II beta subunit modulates N-glycan trimming in fission yeasts and mammals. Stigliano ID, et al. Mol Biol Cell, 2009 Sep. PMID 19605557, Free PMC Article
  5. Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity. Arellano M, et al. J Cell Sci, 1999 Oct. PMID 10504305

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substrate recognition of the catalytic alpha-subunit of glucosidase II from Schizosaccharomyces pombe has been described.
    Title: Substrate recognition of the catalytic α-subunit of glucosidase II from Schizosaccharomyces pombe.
  2. This study reports a 1.6 A resolution crystal structure of the mannose 6-phosphate receptor (MPR) homology domain (MRH) domain of glucosidase II beta bound to mannose.
    Title: Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition.
  3. Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo
    Title: Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables Glc2Man9GlcNAc2 oligosaccharide glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum HDA PubMed 
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucosidase II alpha subunit Gls2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1799915..1803070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018924.3 → NP_593490.1  glucosidase II alpha subunit Gls2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593490.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9US55
    Conserved Domains (3) summary
    COG1501
    Location:59 → 897
    YicI; Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism]
    cd06603
    Location:366 → 834
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:245 → 366
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
Nucleotide Protein
Heading Accession and Version

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