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tip1 CLIP170 family protein Tip1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2543044, updated on 18-Sep-2024

Summary

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Official Symbol
tip1
Official Full Name
CLIP170 family protein Tip1
Primary source
PomBase:SPAC3C7.12
Locus tag
SPOM_SPAC3C7.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
noc1
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Genomic context

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See tip1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2089289..2091311)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene peroxin 13 Neighboring gene ncRNA Neighboring gene calnexin Cnx1 Neighboring gene glucose-6-phosphate 1-dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NAD(P)H dehydrogenase (quinone)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast. Brunner D, et al. Cell, 2000 Sep 1. PMID 11007487
  2. The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules. Busch KE, et al. Curr Biol, 2004 Apr 6. PMID 15062095
  3. Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast. Daga RR, et al. J Cell Sci, 2008 Jun 15. PMID 18495844
  4. Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants. Höög JL, et al. PLoS One, 2013. PMID 23613905, Free PMC Article
  5. Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Wang X, et al. Nat Commun, 2022 Sep 22. PMID 36138017, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S. pombe Tip1/CLIP170 is directly or indirectly required for correct chromosome poleward movement independently of Mal3/EB1.
    Title: Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.
  2. Myo52 facilitates microtubule catastrophe by enhancing Tip1 removal from the plus end of growing microtubules at the cell tips.
    Title: Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding EXP
Inferred from Experiment
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation EXP
Inferred from Experiment
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cytoplasmic microtubule plus-end IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytoplasmic microtubule EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasmic microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
NOT is_active_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle astral microtubule end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in post-anaphase array microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLIP170 family protein Tip1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2089289..2091311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019044.3 → NP_593613.1  CLIP170 family protein Tip1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593613.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P79065
    Conserved Domains (3) summary
    smart01052
    Location:4 → 74
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    pfam15272
    Location:140 → 238
    BBP1_C; Spindle pole body component BBP1, C-terminal
    cl09139
    Location:101 → 187
    FliE; Flagellar hook-basal body complex protein FliE
Nucleotide Protein
Heading Accession and Version

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