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ura3 mitochondrial dihydroorotate dehydrogenase Ura3 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542781, updated on 18-Sep-2024

Summary

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Official Symbol
ura3
Official Full Name
mitochondrial dihydroorotate dehydrogenase Ura3
Primary source
PomBase:SPAC57A10.12c
Locus tag
SPOM_SPAC57A10.12C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ura3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1385357..1387145, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene La-motif domain-containing protein Neighboring gene disulfide relay system thiol oxidase subunit Mia40 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent DNA replication ligase Cdc17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two different dihydroorotate dehydrogenases from yeast Saccharomyces kluyveri. Zameitat E, et al. FEBS Lett, 2004 Jun 18. PMID 15196933
  2. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Nagy M, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1409592, Free PMC Article
  3. Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast. Matsuo Y, et al. PLoS One, 2013. PMID 23555823, Free PMC Article
  4. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
  5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial dihydroorotate dehydrogenase Ura3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1385357..1387145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018748.3 → NP_593317.1  mitochondrial dihydroorotate dehydrogenase Ura3 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593317.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32747
    Conserved Domains (2) summary
    PLN02826
    Location:42 → 431
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:69 → 426
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
Nucleotide Protein
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