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sde2 splicing regulator Sde2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542222, updated on 18-Sep-2024

Summary

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Official Symbol
sde2
Official Full Name
splicing regulator Sde2
Primary source
PomBase:SPAC31G5.18c
Locus tag
SPOM_SPAC31G5.18C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See sde2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (3020648..3021761, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate beta-D-mannosyltransferase catalytic subunit Dpm1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS10 Neighboring gene ncRNA Neighboring gene ATPase histone chaperone Abo1 Neighboring gene ncRNA Neighboring gene triacylglycerol lipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. Sugioka-Sugiyama R, et al. Biochem Biophys Res Commun, 2011 Mar 18. PMID 21333630
  2. Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2. Anil AT, et al. Nucleic Acids Res, 2022 Sep 23. PMID 36095128, Free PMC Article
  3. Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants. Sánchez A, et al. G3 (Bethesda), 2015 Mar 19. PMID 25795664, Free PMC Article
  4. Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe. Cipakova I, et al. Cell Cycle, 2019 Jul. PMID 31219728, Free PMC Article
  5. A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast. Bayne EH, et al. Genome Biol, 2014. PMID 25274039, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.
    Title: Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.
  2. These findings demonstrate that Sde2 cooperates with other telomere regulators to maintain functional telomeres, thereby preventing genomic instability.
    Title: Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of post-mRNA release spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
splicing regulator Sde2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3020648..3021761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019445.3 → NP_594019.1  splicing regulator Sde2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594019.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14113
    Conserved Domains (1) summary
    pfam13019
    Location:4 → 160
    Telomere_Sde2; Telomere stability and silencing
Nucleotide Protein
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