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ddb1 protein Ddb1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542207, updated on 18-Sep-2024

Summary

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Official Symbol
ddb1
Official Full Name
protein Ddb1
Primary source
PomBase:SPAC17H9.10c
Locus tag
SPOM_SPAC17H9.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ddb1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (2020968..2024660, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene coenzyme A transporter Neighboring gene ncRNA Neighboring gene GTPase Ras1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene actin regulatory protein gmf1 Neighboring gene cytochrome c-heme-linkage protein Cyc2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a Schizosaccharomyces pombe strain deleted for a sequence homologue of the human damaged DNA binding 1 (DDB1) gene. Zolezzi F, et al. J Biol Chem, 2002 Oct 25. PMID 12181326
  2. DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1. Ralph E, et al. EMBO Rep, 2006 Nov. PMID 17039252, Free PMC Article
  3. Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage. Bondar T, et al. J Biol Chem, 2004 Mar 12. PMID 14701809
  4. TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation. Wei Y, et al. Nat Cell Biol, 2021 Mar. PMID 33574613, Free PMC Article
  5. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Braun S, et al. Cell, 2011 Jan 7. PMID 21215368, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epe1 is the sole target of the Cul4-Ddb1(Cdt)2 complex whose destruction is necessary for the preservation of heterochromatin.
    Title: The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.
  2. These data indicate that the DDB-box is another common motif which defines adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
    Title: Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
  3. Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase
    Title: Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
  4. We show that Cdt2 and Ddb1 are needed for cell-cycle changes in Cdt1 levels in the absence of DNA damage.
    Title: DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.
  5. Ddb1, along with Cullin 4 and the signalosome, constitute a major pathway controlling genome stability, repair, and differentiation via ribonucleotide reductase regulation.
    Title: Ddb1 controls genome stability and meiosis in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination EXP
Inferred from Experiment
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex EXP
Inferred from Experiment
more info
 PubMed 
part_of Ddb1-Ckn1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ddb1-Wdr21 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Ddb1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    2020968..2024660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019012.3 → NP_593580.1  protein Ddb1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593580.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O13807
    Conserved Domains (3) summary
    pfam03178
    Location:734 → 1033
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:73 → 513
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    cl11493
    Location:444 → 605
    PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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