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pyp2 protein tyrosine phosphatase Pyp2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542200, updated on 18-Sep-2024

Summary

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Official Symbol
pyp2
Official Full Name
protein tyrosine phosphatase Pyp2
Primary source
PomBase:SPAC19D5.01
Locus tag
SPOM_SPAC19D5.01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pyp2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5202656..5205202)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Emc10 Neighboring gene terminal uridylyltransferase Cid1 Neighboring gene E3 ubiquitin-protein ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase. Kowalczyk KM, et al. J Cell Sci, 2013 Aug 1. PMID 23690545
  2. The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast. Mos M, et al. PLoS One, 2013. PMID 23843946, Free PMC Article
  3. Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Degols G, et al. Mol Cell Biol, 1996 Jun. PMID 8649397, Free PMC Article
  4. Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress. Hartmuth S, et al. J Cell Sci, 2009 Jun 1. PMID 19417002
  5. Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast. Gaits F, et al. Mol Biol Cell, 1999 May. PMID 10233152, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitochondrion HDA PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
protein tyrosine phosphatase Pyp2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5202656..5205202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020328.3 → NP_594899.1  protein tyrosine phosphatase Pyp2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594899.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32586, Q9UR59, Q9UU64
    Conserved Domains (3) summary
    COG5599
    Location:405 → 709
    COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]
    cd00047
    Location:461 → 697
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd01446
    Location:4 → 129
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
Nucleotide Protein
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