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fra2 iron-sensor Fra2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542160, updated on 18-Sep-2024

Summary

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Official Symbol
fra2
Official Full Name
iron-sensor Fra2
Primary source
PomBase:SPAC8C9.11
Locus tag
SPOM_SPAC8C9.11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See fra2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (3659089..3659824)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein uS7 Neighboring gene ncRNA Neighboring gene protein mug129 Neighboring gene ribosome biogenesis protein Rrp14-N Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ermes regulator Emr1 Neighboring gene mitochondrial iron ion transporter Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal. Hati D, et al. J Biol Chem, 2023 Dec. PMID 37923140, Free PMC Article
  2. Fra2 is a co-regulator of Fep1 inhibition in response to iron starvation. Jacques JF, et al. PLoS One, 2014. PMID 24897379, Free PMC Article
  3. A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast. Encinar del Dedo J, et al. PLoS Genet, 2015 Mar. PMID 25806539, Free PMC Article
  4. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to transcription coactivator activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to iron ion starvation EXP
Inferred from Experiment
more info
 PubMed 
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular iron ion homeostasis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein maturation by iron-sulfur cluster transfer IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
iron-sensor Fra2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    3659089..3659824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001019705.3 → NP_594282.2  iron-sensor Fra2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594282.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14280
    Conserved Domains (1) summary
    COG0271
    Location:1 → 81
    BolA; Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
Nucleotide Protein
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