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pgt1 plasma membrane glutathione transmembrane transporter Pgt1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2542082, updated on 14-Nov-2024

Summary

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Official Symbol
pgt1
Official Full Name
plasma membrane glutathione transmembrane transporter Pgt1
Primary source
PomBase:SPAC29B12.10c
Locus tag
SPOM_SPAC29B12.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
opt1
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Genomic context

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See pgt1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (5431575..5434787, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene silencing factor Clr5 Neighboring gene ncRNA Neighboring gene WW domain-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pgt1, a glutathione transporter from the fission yeast Schizosaccharomyces pombe. Thakur A, et al. FEMS Yeast Res, 2008 Sep. PMID 18662319
  2. SpOPT1, a member of the oligopeptide family (OPT) of the fission yeast Schizosaccharomyces pombe, is involved in the transport of glutathione through the outer membrane of the cell. Dworeck T, et al. Yeast, 2009 Jan. PMID 19180638
  3. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
  4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
  5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPAC29B12.10c is named SpOPT1 and it localizes within the plasma membrane and transports the glutathione.
    Title: SpOPT1, a member of the oligopeptide family (OPT) of the fission yeast Schizosaccharomyces pombe, is involved in the transport of glutathione through the outer membrane of the cell.
  2. Identified as a gene encoding the S. pombe glutathione transporter (Pgt1) by a genetic strategy that exploited the requirement of the cys1aDelta strain of S. pombe for either cysteine or glutathione, for growth.
    Title: Pgt1, a glutathione transporter from the fission yeast Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables glutathione transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables glutathione transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oligopeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glutathione import across plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
involved_in glutathione import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
plasma membrane glutathione transmembrane transporter Pgt1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5431575..5434787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020418.3 → NP_594987.1  plasma membrane glutathione transmembrane transporter Pgt1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594987.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14031
    Conserved Domains (1) summary
    TIGR00728
    Location:135 → 813
    OPT_sfam; oligopeptide transporter, OPT superfamily
Nucleotide Protein
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