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prw1 histone chaperone, Clr6 and Rpd3L complex subunit Prw1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541804, updated on 18-Sep-2024

Summary

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Official Symbol
prw1
Official Full Name
histone chaperone, Clr6 and Rpd3L complex subunit Prw1
Primary source
PomBase:SPAC29A4.18
Locus tag
SPOM_SPAC29A4.18
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See prw1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003424.3 (5110278..5111882, complement)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Ca(2+)/Mn(2+)-transporting P-type ATPase P5 type Cta5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene integral mitochondrial outer membrane (MOM) protein Neighboring gene serine/threonine protein kinase Hal4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Neural REST/NRSF-SIN3 Transcriptional Corepressor Complex as a Target for Small-Molecule Inhibitors. Jayaprakash S, et al. Mol Biotechnol, 2021 Jan. PMID 33130996
  2. Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. Nakayama J, et al. EMBO J, 2003 Jun 2. PMID 12773392, Free PMC Article
  3. Class I histone deacetylase complex: Structure and functional correlates. Wang X, et al. Proc Natl Acad Sci U S A, 2023 Jul 25. PMID 37459529, Free PMC Article
  4. Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nicolas E, et al. Nat Struct Mol Biol, 2007 May. PMID 17450151
  5. Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase. Kaufmann I, et al. Mol Cell Biol, 2010 Jul. PMID 20404084, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables H3-H4 histone complex chaperone activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
Component Evidence Code Pubs
part_of Rpd3L complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L-Expanded complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3S complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
NOT is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone chaperone, Clr6 and Rpd3L complex subunit Prw1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    5110278..5111882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001020293.3 → NP_594864.1  histone chaperone, Clr6 and Rpd3L complex subunit Prw1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_594864.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14021
    Conserved Domains (4) summary
    COG2319
    Location:99 → 410
    WD40; WD40 repeat [General function prediction only]
    pfam12265
    Location:28 → 96
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    sd00039
    Location:133 → 182
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:110 → 410
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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