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pds5 mitotic and meiotic cohesin loader subunit Pds5 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541628, updated on 18-Sep-2024

Summary

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Official Symbol
pds5
Official Full Name
mitotic and meiotic cohesin loader subunit Pds5
Primary source
PomBase:SPAC110.02
Locus tag
SPOM_SPAC110.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See pds5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003424.3 (1911848..1915897)

Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho family GTPase Cdc42

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5. Folco HD, et al. Genetics, 2019 Sep. PMID 31278118, Free PMC Article
  2. Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction. Vaur S, et al. EMBO Rep, 2012 Jun 29. PMID 22640989, Free PMC Article
  3. Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. Ding DQ, et al. J Cell Biol, 2006 Aug 14. PMID 16893973, Free PMC Article
  4. Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. Ding DQ, et al. Chromosoma, 2016 Jun. PMID 26511279, Free PMC Article
  5. Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism. Tanaka K, et al. EMBO J, 2001 Oct 15. PMID 11598020, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pds5 enriched throughout heterochromatin domains is required for proper maintenance of heterochromatin. This function of Pds5 requires its associated Eso1.
    Title: Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.
  2. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.
    Title: Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
  3. Rec8 and Pds5 play an essential role in building a platform to support the chromosome architecture necessary for the spatial alignment of homologous chromosomes.
    Title: Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
  4. Pds5 is essential for cohesin acetylation by Eso1.
    Title: Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of meiotic spindle microtubules to meiosis II kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Wpl/Pds5 cohesin loading/unloading complex EXP
Inferred from Experiment
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitotic and meiotic cohesin loader subunit Pds5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003424.3 Reference assembly

    Range
    1911848..1915897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018969.3 → NP_593535.1  mitotic and meiotic cohesin loader subunit Pds5 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_593535.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94237, Q9HFF5
    Conserved Domains (1) summary
    sd00044
    Location:244 → 272
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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