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mde4 microtubule-site clamp monopolin complex subunit Mde4 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541155, updated on 18-Sep-2024

Summary

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Official Symbol
mde4
Official Full Name
microtubule-site clamp monopolin complex subunit Mde4
Primary source
PomBase:SPBC6B1.04
Locus tag
SPOM_SPBC6B1.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mde4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2632817..2635971)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ark1/Prk1 family protein kinase Ppk30 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pal1 family early clathrin mediated endocytosis factor, meiosis specific Pal2 Neighboring gene E1 Atg8 and Atg12 E1 activating enzyme Atg7 Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp14 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Laser microsurgery provides evidence for merotelic kinetochore attachments in fission yeast cells lacking Pcs1 or Clr4. Rumpf C, et al. Cell Cycle, 2010 Oct 1. PMID 20935472, Free PMC Article
  2. The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Gregan J, et al. Curr Biol, 2007 Jul 17. PMID 17627824, Free PMC Article
  3. Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation. Choi SH, et al. Curr Biol, 2009 Jun 23. PMID 19523829, Free PMC Article
  4. A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments. Choi SH, et al. Curr Biol, 2012 Feb 7. PMID 22264609, Free PMC Article
  5. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Corbett KD, et al. Cell, 2010 Aug 20. PMID 20723757, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to microtubule site clamp EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome centromere condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, centromeric core domain IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
part_of monopolin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
microtubule-site clamp monopolin complex subunit Mde4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2632817..2635971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021997.3 → NP_596083.1  microtubule-site clamp monopolin complex subunit Mde4 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596083.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O43068
    Conserved Domains (1) summary
    pfam10422
    Location:1 → 408
    LRS4; Monopolin complex subunit LRS4
Nucleotide Protein
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