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txl1 thioredoxin-1-like protein Txl1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541028, updated on 18-Sep-2024

Summary

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Official Symbol
txl1
Official Full Name
thioredoxin-1-like protein Txl1
Primary source
PomBase:SPBC577.08c
Locus tag
SPOM_SPBC577.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
trx3
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Genomic context

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See txl1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (766352..767490, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 1-phosphatidylinositol 4-kinase Stt4 Neighboring gene ubiquitin C-terminal hydrolase Ubp10 Neighboring gene ncRNA Neighboring gene DNA repair ERCC8 family protein ckn1 Neighboring gene proteasome core particle subunit beta 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide. Jiménez A, et al. Yeast, 2007 Jun. PMID 17476701
  2. Using in vivo oxidation status of one- and two-component redox relays to determine H(2)O(2) levels linked to signaling and toxicity. Domènech A, et al. BMC Biol, 2018 Jun 1. PMID 29859088, Free PMC Article
  3. Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach. García-Santamarina S, et al. Antioxid Redox Signal, 2013 May 1. PMID 23121505, Free PMC Article
  4. Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast. Andersen KM, et al. Antioxid Redox Signal, 2011 May 1. PMID 21091378
  5. A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein. Brown JD, et al. Cell Rep, 2013 Dec 12. PMID 24268782, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Txl1 and Txc1 are proteasome co-factors connected with oxidative stress.
    Title: Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.
  2. role of txl1 in the cellular detoxification of alkyl hydroperoxide is exerted through a constitutive transcription of thioredoxin-like 1 protein
    Title: The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin-1-like protein Txl1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    766352..767490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021213.3 → NP_595306.1  thioredoxin-1-like protein Txl1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595306.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9USR1
    Conserved Domains (2) summary
    cd02947
    Location:10 → 103
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:129 → 275
    PITH; PITH domain
Nucleotide Protein
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