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kin1 MARK/PAR-1 kinase Kin1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540792, updated on 18-Sep-2024

Summary

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Official Symbol
kin1
Official Full Name
MARK/PAR-1 kinase Kin1
Primary source
PomBase:SPBC4F6.06
Locus tag
SPOM_SPBC4F6.06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See kin1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2694332..2698128)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene lectin family glycoprotein receptor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Mak5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The protein kinase kin1 is required for cellular symmetry in fission yeast. La Carbona S, et al. Biol Cell, 2004 Mar. PMID 15050371
  2. Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast. Cadou A, et al. Cell Cycle, 2009 Aug. PMID 19597328, Free PMC Article
  3. Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast. La Carbona S, et al. Curr Genet, 2006 Dec. PMID 16988828
  4. The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth. Drewes G, et al. FEBS Lett, 2003 Nov 6. PMID 14596912
  5. A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe. Levin DE, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2236039, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ssp1 promotes cell polarity by phosphorylating the activation loop of the MARK/PAR-1 family kinase Kin1. Additional Kin1 substrates for cell polarity and cytokinesis were also phosphorylated by the DYRK family member Pom1.
    Title: Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
  2. The authors propose that Kin1 is required for a tight link between the plasma membrane and the cell wall.
    Title: Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.
  3. nuclear centering becomes essential when Pom1/Tea1/Tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation
    Title: Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.
  4. Kin1 is required for F-actin polarization in interphase and after completion of mitosis and this function may be essential for cytokinesis in a pom1Delta background.
    Title: Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.
  5. The protein kinase kin1 is encoded by a non essential gene and affects polarised cell growth.
    Title: An overview of the KIN1/PAR-1/MARK kinase family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell growth mode switching, monopolar to bipolar IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis, division site positioning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis, division site positioning EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex of cell tip EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cell cortex of cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring EXP
Inferred from Experiment
more info
 PubMed 
is_active_in new growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in non-growing cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
NOT is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in old cell tip after activation of bipolar cell growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MARK/PAR-1 kinase Kin1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2694332..2698128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022023.3 → NP_596106.1  MARK/PAR-1 kinase Kin1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596106.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74392, P22987
    Conserved Domains (3) summary
    cd12121
    Location:753 → 889
    MARK_C_like; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases, and similar domains
    smart00220
    Location:125 → 395
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14077
    Location:123 → 395
    STKc_Kin1_2; Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version

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