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myo51 myosin type V [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540560, updated on 18-Sep-2024

Summary

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Official Symbol
myo51
Official Full Name
myosin type V
Primary source
PomBase:SPBC2D10.14c
Locus tag
SPOM_SPBC2D10.14C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
myo5
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Genomic context

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See myo51 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (2990178..2994914, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleosome assembly protein Nap2 Neighboring gene UV excision repair protein rhp23 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene telomerase regulator Est1 Neighboring gene ncRNA Neighboring gene peptidyl-tRNA hydrolase Pth1 Neighboring gene protein mhf1 Neighboring gene SHREC complex intermodule linker subunit Clr1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fission yeast Myo51 is a meiotic spindle pole body component with discrete roles during cell fusion and spore formation. Doyle A, et al. J Cell Sci, 2009 Dec 1. PMID 19887589
  2. Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo51 is a component of the cytokinetic actin ring. Win TZ, et al. J Cell Sci, 2001 Jan. PMID 11112691
  3. Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring. Laplante C, et al. Curr Biol, 2015 Aug 3. PMID 26144970, Free PMC Article
  4. Myosin Vs organize actin cables in fission yeast. Lo Presti L, et al. Mol Biol Cell, 2012 Dec. PMID 23051734, Free PMC Article
  5. Distinct Roles of Myosin-II Isoforms in Cytokinesis under Normal and Stressed Conditions. Okada H, et al. iScience, 2019 Apr 26. PMID 30928696, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. modified motility assay showed that the additional binding site anchors Myo51-Rng8/9 so that it can cross-link and slide actin-tropomyosin filaments relative to one another, functions that may explain the role of this motor in contractile ring assembly.
    Title: A single-headed fission yeast myosin V transports actin in a tropomyosin-dependent manner.
  2. We provide evidence that the myosin II protein Myp2 and the myosin V protein Myo51 play roles in recruiting TORC2 to the CAR.We go on to show that TORC2-dependent phosphorylation of actin-capping protein 1 (Acp1, a known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 heterodimer formation and is essential for survival upon stress.
    Title: TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
  3. Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction.
    Title: Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.
  4. Rng8 and Rng9 form oligomers and cluster multiple Myo51 dimers to regulate Myo51 localization and functions during fission yeast cytokinesis.
    Title: The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.
  5. Data show that Myo51 has an important role in regulating spore formation upon completion of meiosis.
    Title: Fission yeast Myo51 is a meiotic spindle pole body component with discrete roles during cell fusion and spore formation.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin contractile ring assembly actin filament bundle convergence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to mating projection actin fusion focus EXP
Inferred from Experiment
more info
 PubMed 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in formin-nucleated actin cable IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating projection actin fusion focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in medial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic actomyosin contractile ring, proximal layer IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex ISM
Inferred from Sequence Model
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin type V

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2990178..2994914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022153.3 → NP_596233.1  myosin type V [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596233.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74805
    Conserved Domains (4) summary
    smart00015
    Location:799 → 820
    IQ; Calmodulin-binding motif
    COG5022
    Location:1 → 1471
    COG5022; Myosin heavy chain [General function prediction only]
    cd15474
    Location:1068 → 1447
    Myo5p-like_CBD_fungal; cargo binding domain of fungal myosin V -like proteins
    cd01380
    Location:79 → 737
    MYSc_Myo5; class V myosin, motor domain
Nucleotide Protein
Heading Accession and Version

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