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tor1 TORC2 serine/threonine protein kinase Tor1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540473, updated on 22-Jun-2024

Summary

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Gene symbol
tor1
Gene description
TORC2 serine/threonine protein kinase Tor1
Locus tag
SPOM_SPBC30D10.10C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Old locus tag
SPBC30D10.10c
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Genomic context

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See tor1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3075748..3083248)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pyruvate dehydrogenase e1 component beta subunit Pdb1 Neighboring gene mitochondrial 37S ribosomal protein mS33 Neighboring gene pig-Q Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER membrane organization protein, HVA22/TB2/DP1 family protein Neighboring gene DNA repair protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nickel induced cell impairments are negatively regulated by the Tor1 kinase in Schizosaccharomyces pombe. Navratilova A, et al. World J Microbiol Biotechnol, 2021 Aug 30. PMID 34458935
  2. TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Petersen J, et al. Nat Cell Biol, 2007 Nov. PMID 17952063
  3. Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. Beuzelin C, et al. PLoS One, 2013. PMID 23826334, Free PMC Article
  4. Rab small GTPase emerges as a regulator of TOR complex 2. Tatebe H, et al. Small GTPases, 2010 Nov. PMID 21625337, Free PMC Article
  5. Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe. Ahamad N, et al. Eur J Cell Biol, 2018 May. PMID 29699848

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nickel induced cell impairments are negatively regulated by the Tor1 kinase in Schizosaccharomyces pombe.
    Title: Nickel induced cell impairments are negatively regulated by the Tor1 kinase in Schizosaccharomyces pombe.
  2. Since Gaf1 was also critical for transcription of per1+ and put4+, Tor-Gaf1 signaling may coordinate transcription of multiple amino acid permeases according to nutrient availability
    Title: Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.
  3. The Gad8 kinase (AKT homologue) phosphorylates fission yeast Tor1 at threonine (T1972) to reduce activity.
    Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
  4. While mutated TORC1 and TORC2 displayed diminished kinase activity and FKBP12/Fkh1-dependent rapamycin sensitivity, their phenotypes were nearly opposite in mitosis.
    Title: The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
  5. Results suggest that S. pombe Tor1 and Tor2 can both act in TORC1, but it is the inhibition of Tor1 as part of TORC1 that promotes mitosis following nutrient stress.
    Title: Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.
  6. Data highlight critical roles for TORC2 and its component Tor1 in chromatin metabolism and in promoting mitotic entry, most notably after recovery from DNA-damaging conditions.
    Title: TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
  7. Tor1 and the Tsc1-2 complex work in parallel positively regulating amino acid uptake through the control of expression of amino acid permeases, and either one is required for growth on a poor nitrogen source.
    Title: Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TORC2 serine/threonine protein kinase Tor1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3075748..3083248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022196.3 → NP_596275.1  TORC2 serine/threonine protein kinase Tor1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596275.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O14356
    Conserved Domains (7) summary
    COG5032
    Location:195 → 2335
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:1952 → 2230
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:2305 → 2335
    FATC; FATC domain
    pfam08771
    Location:1814 → 1911
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:723 → 879
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:144 → 193
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:527 → 553
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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