atf1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: atf1
Primary source: PomBase:SPBC29B5.01
Locus tag: SPOM_SPBC29B5.01
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: gad7; mts1; sss1
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Genomic context

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Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003423.3 (1546217..1549862)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.
Title: Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription.
Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
Title: Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
Sty1 and Atf1 were involved in regulating mitotic slowdown in Schizosaccharomyces pombe under nitrosative stress.
Title: Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe.
study presents evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription; show that Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter thereby preventing Atf1-mediated mitotic acceleration; also show that this opposition of Atf1 functions by Pcr1 extends to the G1-S transition event
Title: Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.
Data suggest that S. pombe 972 expressing a nonphosphorylatable Atf1 variant is more sensitive to oxidative stress because of impaired transcription of subset of stress genes whose expression is controlled by Pap1; in S. pombe 972 expressing phospho-mimicking Atf1 mutant, presence of Sty1 is completely dispensable. (Atf1 = transcription factor Atf1; Sty1 = MAP kinase Sty1; Pap1 = transcription factor Pap1)
Title: Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.
A group of hotspots in fission yeast are associated with sequences similar to the cyclic AMP response element and activated by the ATF/CREB family transcription factor dimer Atf1-Pcr1.
Title: Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots.
The data indicates that the Atf1 transcription factor binding to promoters acts as an effective barrier to fix the +1 nucleosome and phase downstream nucleosome arrays to prevent cryptic transcription.
Title: Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription.
Atf1 binds to the Cdc13 promoter, leading to activation of Cdc13 expression.
Title: The basic leucine zipper domain transcription factor Atf1 directly controls Cdc13 expression and regulates mitotic entry independently of Wee1 and Cdc25 in Schizosaccharomyces pombe.
The data indicate that Atf1 and Pcr1 induce the transcription of agl1, which allows efficient utilization of extracellular maltose.
Title: The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.
Atf1 regulates stress-induced changes in the stability and decay of many RNA transcripts.
Title: A stress-activated, p38 mitogen-activated protein kinase-ATF/CREB pathway regulates posttranscriptional, sequence-dependent decay of target RNAs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	EXP Inferred from Experiment more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin-protein adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables recombination hotspot binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antisense RNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in siRNA-mediated heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	EXP Inferred from Experiment more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of atf1-pcr1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
part_of heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Atf-CREB family transcription factor Atf1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

1546217..1549862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356227.2 → NP_001342974.1 Atf-CREB family transcription factor Atf1 [Schizosaccharomyces pombe]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P52890, P78944

Conserved Domains (3) summary

cd14687
Location:474 → 534

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

pfam09726
Location:280 → 532

Macoilin; Transmembrane protein

pfam11786
Location:152 → 234

Aft1_HRA; Aft1 HRA domain