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syj1 inositol-1,4,5-trisphosphate 5-phosphatase 1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540270, updated on 18-Sep-2024

Summary

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Official Symbol
syj1
Official Full Name
inositol-1,4,5-trisphosphate 5-phosphatase 1
Primary source
PomBase:SPBC2G2.02
Locus tag
SPOM_SPBC2G2.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See syj1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3437470..3440897)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein mS41 Neighboring gene plasma membrane pantothenate transmembrane transporter Liz1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translocon beta subunit Sbh1 Neighboring gene mitochondrial matrix protein, YjgF family protein Mmf1, reactive intermediate imine deaminase A homolog Mmf1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Tsujishita Y, et al. Cell, 2001 May 4. PMID 11348594
  2. Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. Chi Y, et al. J Biol Chem, 2004 Oct 22. PMID 15316017
  3. Analysis of the contribution of phosphoinositides to medial septation in fission yeast highlights the importance of PI(4,5)P(2) for medial contractile ring anchoring. Snider CE, et al. Mol Biol Cell, 2018 Sep 1. PMID 29975157, Free PMC Article
  4. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
  5. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reports the crystal structure of the catalytic domain of S. pombe synaptojanin (SPsynaptojanin) alone at 2.0 angstrom resolution, and in a product complex with inositol (1,4)-bisphosphate and calcium at 1.8 angstrom resolution.
    Title: Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
  2. Schizosaccharomyces pombe synaptojanin (SPsynaptojanin) and human SH2 domain-containing inositol-5-phosphatase SHIP2 comparative study: mechanism and substrate specificity. [SPsynaptojanin]
    Title: Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-2,4,5-triphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-4,5,6-triphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-4,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site HDA PubMed 
is_active_in cell tip HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol-1,4,5-trisphosphate 5-phosphatase 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3437470..3440897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022350.3 → NP_596431.1  inositol-1,4,5-trisphosphate 5-phosphatase 1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596431.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O43001
    Conserved Domains (4) summary
    cd09090
    Location:558 → 848
    INPP5c_ScInp51p-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Saccharomyces cerevisiae Inp51p, Inp52p, and Inp53p, and related proteins
    COG5329
    Location:1 → 582
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    COG5411
    Location:529 → 981
    COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]
    pfam02383
    Location:60 → 374
    Syja_N; SacI homology domain
Nucleotide Protein
Heading Accession and Version

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