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mph1 dual-specificity protein kinase Mph1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540060, updated on 18-Sep-2024

Summary

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Official Symbol
mph1
Official Full Name
dual-specificity protein kinase Mph1
Primary source
PomBase:SPBC106.01
Locus tag
SPOM_SPBC106.01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mps1; SPBC1271.16c; SPBC243.01
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Genomic context

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See mph1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (373794..376292)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene oligosaccharyltransferase subunit Stt3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box protein Pof13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sulfiredoxin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast. Chmielewska AE, et al. Cell Cycle, 2016. PMID 26900649, Free PMC Article
  2. Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation. Jian Y, et al. J Biol Chem, 2024 Jan. PMID 38097187, Free PMC Article
  3. Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. He X, et al. J Cell Sci, 1998 Jun. PMID 9601094
  4. The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport. Salus SS, et al. Mol Cell Biol, 2002 Dec. PMID 12446769, Free PMC Article
  5. A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe. Kovacikova I, et al. Cell Cycle, 2013 Feb 15. PMID 23370392, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation.
    Title: Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation.
  2. Phosphorylation of the conserved MELT motifs in Spc7 by Mph1 (Mps1) recruits Bub1 and Bub3 to the kinetochore and this is required to maintain the spindle assembly checkpoint signal. [Bub1; Bub3; Spc7; Mph1]
    Title: Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.
  3. The Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1.
    Title: The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.
  4. Our results highlight the crucial role of Mph1 at kinetochores and suggest that the Mad1-Mad2 complex does not necessarily need to be enriched at kinetochores for functional SAC signaling.
    Title: Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores.
  5. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit spindle assembly checkpoint proteins and promote chromosome alignment.
    Title: MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
  6. A kinase-dead allele of the fission yeast MPS1 homolog (Mph1) is checkpoint defective and levels of anaphase promoting complex-associated Mad2 and Mad3 are dramatically reduced in this mutant.
    Title: Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic centromeric cohesion protection in anaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual-specificity protein kinase Mph1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    373794..376292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021059.4 → NP_595150.2  dual-specificity protein kinase Mph1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595150.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94235, Q9P7Z5, Q9URW0
    Conserved Domains (2) summary
    smart00220
    Location:316 → 603
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14131
    Location:315 → 603
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
Nucleotide Protein
Heading Accession and Version

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