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reb1 RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539930, updated on 22-Jun-2024

Summary

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Gene symbol
reb1
Gene description
RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1
Locus tag
SPOM_SPBC1198.11C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPBC660.01c
Old locus tag
SPBC1198.11c
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Genomic context

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See reb1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (191752..193609, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dipeptidase Dug1 Neighboring gene asparagine--tRNA (Asn) ligase Slm5 Neighboring gene ubiquitin conjugating enzyme Ubc16 Neighboring gene ncRNA Neighboring gene transcription factor TFIIF complex beta subunit Tfg2 Neighboring gene ubiquitin ligase Mfr1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex. Jaiswal R, et al. Acta Crystallogr F Struct Biol Commun, 2015 Apr. PMID 25849502, Free PMC Article
  2. Regulation of replication termination by Reb1 protein-mediated action at a distance. Singh SK, et al. Cell, 2010 Sep 17. PMID 20850009, Free PMC Article
  3. Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe. Biswas S, et al. Mol Cell Biol, 2008 Nov. PMID 18794373, Free PMC Article
  4. Transcription termination factor reb1p causes two replication fork barriers at its cognate sites in fission yeast ribosomal DNA in vivo. Sánchez-Gorostiaga A, et al. Mol Cell Biol, 2004 Jan. PMID 14673172, Free PMC Article
  5. Molecular cloning and analysis of Schizosaccharomyces pombe Reb1p: sequence-specific recognition of two sites in the far upstream rDNA intergenic spacer. Zhao A, et al. Nucleic Acids Res, 1997 Feb 15. PMID 9016645, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
    Title: Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
  2. Reb1 acts as a link between rDNA metabolism and cell cycle control in response to nutritional stress.
    Title: The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.
  3. Study shows that Reb1-dependent Ter sites of S. pombe do not function solely in isolation but communicate pairwise with other such sites either by DNA looping or by chromosome kissing to regulate the magnitude of physiologically programmed fork arrest.
    Title: Regulation of replication termination by Reb1 protein-mediated action at a distance.
  4. These observations suggest that replication fork arrest is not an intrinsic property of the Reb1-Ter3 complex.
    Title: Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rDNA spacer replication fork barrier binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables rDNA spacer replication fork barrier binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription termination site sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cis-acting DNA replication termination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork arrest IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork arrest at rDNA repeats IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork arrest involved in DNA replication termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase I transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in termination of RNA polymerase I transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolar peripheral inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of rDNA heterochromatin EXP
Inferred from Experiment
more info
 PubMed 

General protein information

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Preferred Names
RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    191752..193609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356228.2 → NP_001342963.1  RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94422, Q9P6H9
    Conserved Domains (1) summary
    COG5147
    Location:2 → 504
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
Nucleotide Protein
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