U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

imp1 importin alpha family nuclear import signal receptor adaptor Imp1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539928, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
imp1
Official Full Name
importin alpha family nuclear import signal receptor adaptor Imp1
Primary source
PomBase:SPBC1604.08c
Locus tag
SPOM_SPBC1604.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See imp1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (3916555..3918514)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene exoribonuclease Rex4 Neighboring gene ncRNA Neighboring gene F0-ATPase subunit atp4 Neighboring gene Mak21 family protein Neighboring gene ncRNA Neighboring gene glucose-6-phosphate isomerase Neighboring gene thiamine pyrophosphate transporter

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects. Tallada VA, et al. Yeast, 2002 Sep 30. PMID 12237855
  2. Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast. Flor-Parra I, et al. Cell Rep, 2018 Apr 24. PMID 29694900
  3. The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression. Umeda M, et al. Genetics, 2005 Sep. PMID 15937127, Free PMC Article
  4. Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in Schizosaccharomyces pombe. Asadi F, et al. G3 (Bethesda), 2017 Feb 9. PMID 28040778, Free PMC Article
  5. Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. Khan MG, et al. PLoS One, 2014. PMID 25330182, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results suggest a model in which LatA-mediated cytoskeletal perturbations are sensed, triggering the Imp1p-dependent translocation of Pap1p to the nucleus and the induction of the caf5 gene (independently of oxidative stress).
    Title: Latrunculin A-Induced Perturbation of the Actin Cytoskeleton Mediates Pap1p-Dependent Induction of the Caf5p Efflux Pump in Schizosaccharomyces pombe.
  2. Further analysis by pull-down experiments revealed that Php4 is a cargo of the karyopherins Imp1, Cut15 and Sal3.
    Title: Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.
  3. Imp1p is essential for efficient nuclear protein import in S. pombe.
    Title: The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables GTP binding NAS
Non-traceable Author Statement
more info
  
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic nuclear pore complex disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic nuclear envelope disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope HDA PubMed 
is_active_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
importin alpha family nuclear import signal receptor adaptor Imp1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3916555..3918514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022553.3 → NP_596632.1  importin alpha family nuclear import signal receptor adaptor Imp1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596632.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94374
    Conserved Domains (5) summary
    COG5064
    Location:1 → 531
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:114 → 235
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:9 → 99
    IBB; Importin beta binding domain
    pfam16186
    Location:462 → 508
    Arm_3; Atypical Arm repeat
    sd00043
    Location:115 → 147
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous