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asf1 histone H3-H4 chaperone Asf1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539568, updated on 18-Sep-2024

Summary

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Official Symbol
asf1
Official Full Name
histone H3-H4 chaperone Asf1
Primary source
PomBase:SPCC663.05c
Locus tag
SPOM_SPCC663.05C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
cia1
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Genomic context

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See asf1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1642902..1644584, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene leptomycin transmembrane transporter Pmd1 Neighboring gene ncRNA Neighboring gene GTPAse-interacting protein Neighboring gene 60S ribosomal protein L39 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast. Umehara T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Nov 1. PMID 16511210, Free PMC Article
  2. Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression. Umeda M, et al. Mol Cell Biol, 2018 Sep 15. PMID 29967244, Free PMC Article
  3. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast. Tanae K, et al. FEBS Lett, 2012 Nov 30. PMID 23089178
  4. The HIRA complex subunit Hip3 plays important roles in the silencing of meiosis-specific genes in Schizosaccharomyces pombe. Mizuki F, et al. PLoS One, 2011 Apr 29. PMID 21559379, Free PMC Article
  5. Histone deposition promotes recombination-dependent replication at arrested forks. Hardy J, et al. PLoS Genet, 2019 Oct. PMID 31584934, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of strains carrying either gene disruptions or mutations affecting nine histone chaperone genes demonstrated that the histone chaperone Asf1 induces nucleosome loading during glucose repression. These data establish a previously unappreciated chromatin reconstitution mechanism in fbp1 repression.
    Title: Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.
  2. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
    Title: Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
  3. Asf1 plays an essential role in maintaining genomic stability in S. pombe.
    Title: Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.
  4. crystallographic analysis of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2 subunit of CAF-1 (Cac2C)
    Title: Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.
  5. X-ray diffraction analysis of the histone chaperone cia1 from fission yeast
    Title: Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables H3-H4 histone complex chaperone activity NAS
Non-traceable Author Statement
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone H3-H4 chaperone Asf1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1642902..1644584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023257.3 → NP_588267.1  histone H3-H4 chaperone Asf1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588267.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74515
    Conserved Domains (1) summary
    COG5137
    Location:1 → 174
    COG5137; Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics]
Nucleotide Protein
Heading Accession and Version

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