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hta1 histone H2A alpha [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539499, updated on 18-Sep-2024

Summary

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Official Symbol
hta1
Official Full Name
histone H2A alpha
Primary source
PomBase:SPCC622.08c
Locus tag
SPOM_SPCC622.08C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See hta1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1411144..1412181, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone H2B Htb1 Neighboring gene exocyst complex subunit Sec5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast. Nakamura TM, et al. Mol Cell Biol, 2005 Dec. PMID 16314498, Free PMC Article
  2. BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint. Sofueva S, et al. Mol Cell Biol, 2010 Oct. PMID 20679485, Free PMC Article
  3. Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation. Sanders SL, et al. Mol Cell Biol, 2010 Oct. PMID 20679488, Free PMC Article
  4. Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase. Reubens MC, et al. Mol Cell Biol, 2017 Nov 15. PMID 28784724, Free PMC Article
  5. gammaH2A binds Brc1 to maintain genome integrity during S-phase. Williams JS, et al. EMBO J, 2010 Mar 17. PMID 20094029, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding ISM
Inferred from Sequence Model
more info
  
enables chromatin-protein adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables chromatin-protein adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone H2A alpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1411144..1412181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023170.3 → NP_588180.1  histone H2A alpha [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588180.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P04909
    Conserved Domains (2) summary
    PTZ00017
    Location:4 → 131
    PTZ00017; histone H2A; Provisional
    cd00074
    Location:5 → 120
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Nucleotide Protein
Heading Accession and Version

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