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epe1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539481, updated on 11-Sep-2024

Summary

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Official Symbol
epe1
Primary source
PomBase:SPCC622.16c
Locus tag
SPOM_SPCC622.16C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
kdm2
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1431048..1435041, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase-activating protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP endonuclease, minor transcript isoform Apn1 Neighboring gene siderophore-Fe(3+) transporter Str2 Neighboring gene 60S ribosomal protein eL6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast. Asanuma T, et al. Genes Dev, 2022 Nov-Dec 1. PMID 36617881, Free PMC Article
  2. Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1. Sorida M, et al. PLoS Genet, 2019 Jun. PMID 31206516, Free PMC Article
  3. Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin. Sweta K, et al. Mol Microbiol, 2021 Jul. PMID 33533152
  4. Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2. Chen Y, et al. Sci Rep, 2017 Jun 9. PMID 28600551, Free PMC Article
  5. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. Garcia JF, et al. G3 (Bethesda), 2015 May 8. PMID 25957277, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.
    Title: Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.
  2. The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
    Title: The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
  3. Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
    Title: Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
  4. Our results suggest that Epe1 not only limits the distribution of heterochromatin but also controls the balance between suppression and retention of heterochromatin-mediated epigenetic diversification.
    Title: Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.
  5. Overexpressed Epe1 associates with SAGA and recruits SAGA to heterochromatin regions, which leads to increased histone acetylation, transcription of repeats, and the disruption of heterochromatin.
    Title: Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
  6. Deletion of epe1 (+) impairs downstream events following phosphorylation of Ssp2, including nuclear translocation of Ssp2, sexual differentiation and inhibition of fatty acid synthesis. Our study reveals a novel way in which a jmjC-domain-containing protein regulates adaptive response by directly binding to a principal sensor.
    Title: Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2.
  7. Bdf2 is enriched at IRCs through its interaction with the boundary protein Epe1.
    Title: Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
  8. Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains. The authors propose that Epe1 regulates heterochromatin assembly and disassembly .
    Title: The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.
  9. an interplay between the repressive HDACs activity and Epe1 helps to regulate gene expression
    Title: Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 demethylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterochromatin boundary formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterochromatin boundary formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of regulatory ncRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of siRNA-independent facultative heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin island IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mating-type region heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of subtelomeric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Jmjc domain-containing protein Epe1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1431048..1435041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023178.3 → NP_588188.1  Jmjc domain-containing protein Epe1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588188.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94603
    Conserved Domains (1) summary
    cl21464
    Location:284 → 385
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version

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