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ANGPTL5 angiopoietin like 5 [ Homo sapiens (human) ]

Gene ID: 253935, updated on 14-Nov-2024

Summary

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Official Symbol
ANGPTL5provided by HGNC
Official Full Name
angiopoietin like 5provided by HGNC
Primary source
HGNC:HGNC:19705
See related
Ensembl:ENSG00000187151 MIM:607666; AllianceGenome:HGNC:19705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable signaling receptor binding activity. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary (RPKM 8.8), fat (RPKM 1.3) and 3 other tissues See more
Orthologs
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Genomic context

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See ANGPTL5 in Genome Data Viewer
Location:
11q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (101890674..101916522, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (101891789..101917633, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (101761405..101787253, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K member 25 Env polyprotein Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:101578771-101579411 Neighboring gene PLS1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5433 Neighboring gene centrosomal protein 126 Neighboring gene proline rich 21 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:101834504-101835703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:101880742-101881368 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:101881654-101882853 Neighboring gene uncharacterized LOC124902842 Neighboring gene cilia and flagella associated protein 300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome.
    Title: Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome.
  2. Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents.
    Title: Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents.
  3. CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice
    Title: Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.
  4. Maps to 11q22, mainly expressed in adult human heart.
    Title: Identification of a novel human angiopoietin-like gene expressed mainly in heart.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiopoietin-related protein 5
Names
angiopoietin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178127.5 → NP_835228.2  angiopoietin-related protein 5 precursor

    See identical proteins and their annotated locations for NP_835228.2

    Status: VALIDATED

    Source sequence(s)
    AK291523, AP003383, BC049170
    Consensus CDS
    CCDS8312.1
    UniProtKB/Swiss-Prot
    A8K658, Q86VR9, Q86XS5
    Related
    ENSP00000335255.3, ENST00000334289.7
    Conserved Domains (1) summary
    cd00087
    Location:146 → 382
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    101890674..101916522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017466.3 → XP_016872955.1  angiopoietin-related protein 5 isoform X2

  2. XM_011542735.4 → XP_011541037.1  angiopoietin-related protein 5 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:115 → 317
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    101891789..101917633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368285.1 → XP_054224260.1  angiopoietin-related protein 5 isoform X2

  2. XM_054368284.1 → XP_054224259.1  angiopoietin-related protein 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XS5.3 GenPept UniProtKB/Swiss-Prot:Q86XS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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