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msh6 DNA mismatch repair protein [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539215, updated on 18-Sep-2024

Summary

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Official Symbol
msh6
Official Full Name
DNA mismatch repair protein
Primary source
PomBase:SPCC285.16c
Locus tag
SPOM_SPCC285.16C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See msh6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1827452..1831706, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene TRAPP complex subunit Trs130 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS28 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase I upstream activation factor complex subunit Spp27 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe. Tornier C, et al. Genetics, 2001 May. PMID 11333218, Free PMC Article
  2. Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Mansour AA, et al. Genetics, 2001 May. PMID 11333219, Free PMC Article
  3. The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination. Saito Y, et al. Sci Rep, 2013. PMID 23779158, Free PMC Article
  4. Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility. Zamir L, et al. Proc Natl Acad Sci U S A, 2012 Feb 14. PMID 22308326, Free PMC Article
  5. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. McDonald KR, et al. PLoS Genet, 2016 Sep. PMID 27611590, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
  
enables mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA mismatch repair protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1827452..1831706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023335.3 → NP_588344.1  DNA mismatch repair protein [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588344.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74502
    Conserved Domains (6) summary
    cd03286
    Location:988 → 1201
    ABC_MSH6_euk; ATP-binding cassette domain of eukaryotic MutS6 homolog
    COG0249
    Location:369 → 1254
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:376 → 493
    MutS_I; MutS domain I
    pfam05188
    Location:502 → 645
    MutS_II; MutS domain II
    pfam05190
    Location:835 → 924
    MutS_IV; MutS family domain IV
    pfam05192
    Location:671 → 794
    MutS_III; MutS domain III
Nucleotide Protein
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