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mis16 histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539214, updated on 18-Sep-2024

Summary

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Official Symbol
mis16
Official Full Name
histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16
Primary source
PomBase:SPCC1672.10
Locus tag
SPOM_SPCC1672.10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See mis16 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003421.2 (584126..585893)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-type ATPase P5 type Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A(Cnp1)-Specific Assembly Factor through Eic1 Interaction. An S, et al. Structure, 2018 Jul 3. PMID 29804820, Free PMC Article
  2. Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp. An S, et al. J Mol Biol, 2015 Oct 9. PMID 26343758
  3. Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe. Gao C, et al. Genetics, 2017 Oct. PMID 28827290, Free PMC Article
  4. The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A. Hirai H, et al. PLoS One, 2014. PMID 25375240, Free PMC Article
  5. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. Tong K, et al. Eukaryot Cell, 2012 Sep. PMID 22771823, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results find that the C terminus of Mis19 binds to Mis16 by engaging the histone H4-binding pocket on Mis16.
    Title: Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
  2. Ccp1 interacts with CENP-A and is recruited to centromeres at the end of mitosis in a Mis16-dependent manner.
    Title: Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading.
  3. Mis16-Mis18-Mis19-Mis20 CENP-A-recruiting complex, which is functional in the G1-S phase, may be counteracted by the SWI/SNF chromatin-remodeling complex and non-sense-mediated mRNA decay, which may prevent CENP-A deposition at the centromere.
    Title: Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
  4. Mis16 is physically associated with Hat1.
    Title: Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
  5. we report that the Mis16-Mis18 complex is required for centromere localization of Scm3(Sp)
    Title: Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables H3-H4 histone complex chaperone activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CENP-A recruiting complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    584126..585893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022873.3 → NP_587881.1  histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587881.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94244
    Conserved Domains (3) summary
    cd00200
    Location:130 → 418
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:135 → 180
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:28 → 98
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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