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dcr1 dicer [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538930, updated on 18-Sep-2024

Summary

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Official Symbol
dcr1
Official Full Name
dicer
Primary source
PomBase:SPCC188.13c
Locus tag
SPOM_SPCC188.13C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPCC584.10c
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Genomic context

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See dcr1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (1504949..1510557, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prp19 complex subunit Prp45 Neighboring gene septin Spn6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER to Golgi ceramide transport protein, lipocalin superfamily Svf1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that in S. pombe Dcr1 has a genome-wide role in terminating transcription by releasing Pol II at sites of collision between transcription and replication and thus maintains genome stability.
    Title: Dicer promotes transcription termination at sites of replication stress to maintain genome stability.
  2. Studies indicate that S. pombe genome encodes one of each of the core RNAi proteins, Dicer, Argonaute and RNA-dependent RNA polymerase (dcr1, ago1, rdp1).
    Title: RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe.
  3. Data indicate that Argonaute, loaded with longer RNA precursors, recruits Triman (SPBC29A10.09c, 3'-5' Exonuclease) to generate dicer-independent priRNAs mature priRNAs and siRNAs.
    Title: Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.
  4. these results reveal novel insights into the mechanism of nuclear retention of Dcr1 and raise the possibility that this new class of dsRBDs might generally function in nucleocytoplasmic trafficking and not substrate binding
    Title: An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer.
  5. Dcr1 has a role in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe [review]
    Title: Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables euchromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in co-transcriptional gene silencing by RNA interference machinery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G0 to G1 transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siRNA-mediated pericentric heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in siRNA-mediated pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in termination of RNA polymerase I transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase II transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase III transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dicer

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1504949..1510557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023205.3 → NP_588215.2  dicer [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588215.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q09884, Q9UUN1
    Conserved Domains (7) summary
    smart00535
    Location:912 → 1045
    RIBOc; Ribonuclease III family
    COG0571
    Location:1076 → 1345
    Rnc; dsRNA-specific ribonuclease [Transcription]
    COG1111
    Location:1 → 501
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:26 → 188
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:1098 → 1247
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam00271
    Location:343 → 464
    Helicase_C; Helicase conserved C-terminal domain
    pfam03368
    Location:538 → 620
    Dicer_dimer; Dicer dimerization domain
Nucleotide Protein
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