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set1 histone H3-K4 methyltransferase Set1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538762, updated on 14-Nov-2024

Summary

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Official Symbol
set1
Official Full Name
histone H3-K4 methyltransferase Set1
Primary source
PomBase:SPCC306.04c
Locus tag
SPOM_SPCC306.04C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
kmt2
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Genomic context

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See set1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (412293..415947, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rab GTPase-binding protein Neighboring gene condensin complex non-SMC subunit Cnd2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSIG domain protein Neighboring gene ncRNA Neighboring gene family protein BIG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Noma K, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12193658, Free PMC Article
  2. Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex. Mikheyeva IV, et al. PLoS Genet, 2014 Oct. PMID 25356590, Free PMC Article
  3. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Yamada S, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23382177, Free PMC Article
  4. Histone deacetylation promotes transcriptional silencing at facultative heterochromatin. Watts BR, et al. Nucleic Acids Res, 2018 Jun 20. PMID 29618061, Free PMC Article
  5. Suppression of Meiotic Recombination by CENP-B Homologs in Schizosaccharomyces pombe. Johansen P, et al. Genetics, 2015 Nov. PMID 26354768, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we describe the impact of silencing and clustering on the mobility of an endogenous Tf2 element. Deletion of genes such as set1(+) or abp1(+) that both alleviate silencing and clustering, result in a corresponding increase in mobilization. Furthermore, expression of constitutively active Sre1, a transcriptional activator of Tf2 elements, also alleviates clustering and induces mobilization
    Title: Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.
  2. Heterochromatin assembly and transcriptome repression is mediated by Set1 in coordination with Clr3.
    Title: Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase.
  3. the regulation of Set1 protein level is not coupled to the status of H3K4me or histone H2B ubiquitination by the HULC complex
    Title: Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.
  4. The results suggest that meiotic DNA double-strand break formation is redundantly regulated by multiple chromatin-related factors including H3K9ac and Set1 in fission yeast.
    Title: Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast.
  5. An unexpected cooperation between Abp1 and the histone H3K4 methyltransferase Set1 was uncovered in regulating sense and antisense transcriptional silencing of Tf2 retrotransposons and Tf body integrity, largely independent of H3K4 methylation.
    Title: CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.
  6. trans-histone crosstalk in S. pombe involves direct enhancement of Set1C methyltransferase activity by H2Bub1 and suggest that this represents a conserved aspect of H2Bub1-H3K4me crosstalk in eukaryotes.
    Title: Histone H2B ubiquitylation promotes activity of the intact Set1 histone methyltransferase complex in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K4 trimethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in siRNA-independent facultative heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IC
Inferred by Curator
more info
  
involved_in transposable element silencing by heterochromatin formation EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IC
Inferred by Curator
more info
  
is_active_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
histone H3-K4 methyltransferase Set1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    412293..415947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022805.3 → NP_587812.1  histone H3-K4 methyltransferase Set1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587812.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7R4
    Conserved Domains (7) summary
    smart00317
    Location:783 → 899
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:904 → 920
    PostSET; Cysteine-rich motif following a subset of SET domains
    COG0724
    Location:90 → 226
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    COG2940
    Location:457 → 920
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd12303
    Location:96 → 180
    RRM_spSet1p_like; RNA recognition motif in fission yeast Schizosaccharomyces pombe SET domain-containing protein 1 (spSet1p) and similar proteins
    pfam11764
    Location:641 → 771
    N-SET; COMPASS (Complex proteins associated with Set1p) component N
    pfam11767
    Location:279 → 342
    SET_assoc; Histone lysine methyltransferase SET associated
Nucleotide Protein
Heading Accession and Version

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