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GPATCH11 G-patch domain containing 11 [ Homo sapiens (human) ]

Gene ID: 253635, updated on 28-Oct-2024

Summary

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Official Symbol
GPATCH11provided by HGNC
Official Full Name
G-patch domain containing 11provided by HGNC
Primary source
HGNC:HGNC:26768
See related
Ensembl:ENSG00000152133 AllianceGenome:HGNC:26768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENPY; CCDC75; CENP-Y
Summary
Predicted to enable nucleic acid binding activity. Located in kinetochore. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in fat (RPKM 17.4), testis (RPKM 7.9) and 23 other tissues See more
Orthologs
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Genomic context

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See GPATCH11 in Genome Data Viewer
Location:
2p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (37084518..37099244)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (37091653..37106376)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37311661..37326387)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene RNA, U6 small nuclear 577, pseudogene Neighboring gene MPRA-validated peak3656 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:37189639-37189834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11352 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:37230067-37230233 Neighboring gene HEAT repeat containing 5B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15579 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11354 Neighboring gene ARL14EP pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:37416294-37416819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:37416820-37417344 Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ribosomal protein L31 pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. Chen J, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12213963, Free PMC Article
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  3. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Ozyildirim AM, et al. Invest Ophthalmol Vis Sci, 2005 May. PMID 15851553
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031, Free PMC Article
  5. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. Abbasi S, et al. J Proteome Res, 2019 Mar 1. PMID 30585729

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38348

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G patch domain-containing protein 11
Names
centromere protein Y
coiled-coil domain containing 75
coiled-coil domain-containing protein 75
g patch domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278505.2 → NP_001265434.1  G patch domain-containing protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001265434.1

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/TrEMBL
    A0A6Q8JGY2
    Related
    ENSP00000281932.6, ENST00000281932.6
    Conserved Domains (1) summary
    pfam13821
    Location:108 → 155
    DUF4187; Domain of unknown function (DUF4187)

  2. NM_001322249.4 → NP_001309178.3  G patch domain-containing protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    Conserved Domains (3) summary
    COG5281
    Location:34 → 166
    COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
    pfam01585
    Location:74 → 109
    G-patch; G-patch domain
    pfam13821
    Location:201 → 248
    DUF4187; Domain of unknown function (DUF4187)

  3. NM_001371856.3 → NP_001358785.2  G patch domain-containing protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    Conserved Domains (2) summary
    smart00443
    Location:74 → 117
    G_patch; glycine rich nucleic binding domain
    pfam13821
    Location:223 → 270
    DUF4187; Domain of unknown function (DUF4187)

  4. NM_001371858.3 → NP_001358787.2  G patch domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007899
    Consensus CDS
    CCDS1785.4
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    UniProtKB/TrEMBL
    A0A6I8PRS5
    Conserved Domains (2) summary
    pfam01585
    Location:74 → 117
    G-patch; G-patch domain
    pfam13821
    Location:215 → 262
    DUF4187; Domain of unknown function (DUF4187)

  5. NM_001371859.3 → NP_001358788.2  G patch domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007899
    Consensus CDS
    CCDS1785.4
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    UniProtKB/TrEMBL
    A0A6I8PRS5
    Conserved Domains (2) summary
    pfam01585
    Location:74 → 117
    G-patch; G-patch domain
    pfam13821
    Location:215 → 262
    DUF4187; Domain of unknown function (DUF4187)

  6. NM_001371860.3 → NP_001358789.2  G patch domain-containing protein 11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    Conserved Domains (2) summary
    smart00443
    Location:74 → 116
    G_patch; glycine rich nucleic binding domain
    pfam13821
    Location:214 → 261
    DUF4187; Domain of unknown function (DUF4187)

  7. NM_001371861.3 → NP_001358790.2  G patch domain-containing protein 11 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    Conserved Domains (2) summary
    smart00443
    Location:74 → 116
    G_patch; glycine rich nucleic binding domain
    pfam13821
    Location:214 → 261
    DUF4187; Domain of unknown function (DUF4187)

  8. NM_001371862.3 → NP_001358791.2  G patch domain-containing protein 11 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC007899
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    Conserved Domains (2) summary
    smart00443
    Location:74 → 117
    G_patch; glycine rich nucleic binding domain
    pfam13821
    Location:212 → 259
    DUF4187; Domain of unknown function (DUF4187)

  9. NM_174931.4 → NP_777591.4  G patch domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007899, AK095667, AK294697
    Consensus CDS
    CCDS1785.4
    UniProtKB/Swiss-Prot
    A0A0A0MSF9, A8K0D9, B7Z2G4, B8ZZ44, Q8N954
    UniProtKB/TrEMBL
    A0A6I8PRS5
    Related
    ENSP00000501347.1, ENST00000674370.2
    Conserved Domains (2) summary
    pfam01585
    Location:74 → 117
    G-patch; G-patch domain
    pfam13821
    Location:215 → 262
    DUF4187; Domain of unknown function (DUF4187)

RNA

  1. NR_163986.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007899

  2. NR_163987.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007899

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    37084518..37099244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    37091653..37106376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N954.4 GenPept UniProtKB/Swiss-Prot:Q8N954

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