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Cox6a2 cytochrome c oxidase subunit 6A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25278, updated on 2-Nov-2024

Summary

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Official Symbol
Cox6a2provided by RGD
Official Full Name
cytochrome c oxidase subunit 6A2provided by RGD
Primary source
RGD:2385
See related
EnsemblRapid:ENSRNOG00000019851 AllianceGenome:RGD:2385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
COX6AH
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 9042.9) and Muscle (RPKM 5778.6) See more
Orthologs
human mouse all
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Genomic context

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See Cox6a2 in Genome Data Viewer
Location:
1q37
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192218970..192221188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182788528..182790746, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199624037..199626255, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D Neighboring gene RIKEN cDNA 9130023H24 gene like Neighboring gene armadillo repeat containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural organisation of the rat genes encoding liver- and heart-type of cytochrome c oxidase subunit VIa and a pseudogene related to the COXVIa-L cDNA. Mell OC, et al. Gene, 1994 Mar 25. PMID 8144025
  2. Characterization of two different genes (cDNA) for cytochrome c oxidase subunit VIa from heart and liver of the rat. Schlerf A, et al. EMBO J, 1988 Aug. PMID 2461293, Free PMC Article
  3. Tissue- and species-specific expression of cytochrome c oxidase isozymes in vertebrates. Kadenbach B, et al. Biochim Biophys Acta, 1990 Feb 2. PMID 2153407
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytochrome-c oxidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6A2, mitochondrial
Names
COXVIAH
cytochrome c oxidase polypeptide VIa-heart
cytochrome c oxidase subunit VIa polypeptide 2 (heart)
NP_036944.2
XP_006230280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012812.3 → NP_036944.2  cytochrome c oxidase subunit 6A2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036944.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript.
    Source sequence(s)
    BQ782365, FM058713
    UniProtKB/Swiss-Prot
    P10817
    UniProtKB/TrEMBL
    A6I9Y9, G3V8M4
    Related
    ENSRNOP00000026908.2, ENSRNOT00000026908.6
    Conserved Domains (1) summary
    cd00925
    Location:13 → 95
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RNA

  1. NR_037674.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in a 5' exon, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BQ782365, FM058713, FM121690

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    192218970..192221188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230218.1 → XP_006230280.1  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006230280.1

    UniProtKB/Swiss-Prot
    P10817
    UniProtKB/TrEMBL
    A6I9Y9, G3V8M4
    Conserved Domains (1) summary
    cd00925
    Location:13 → 95
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10817.3 GenPept UniProtKB/Swiss-Prot:P10817

Gene LinkOut

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