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FUT3 fucosyltransferase 3 (Lewis blood group) [ Homo sapiens (human) ]

Gene ID: 2525, updated on 2-Nov-2024

Summary

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Official Symbol
FUT3provided by HGNC
Official Full Name
fucosyltransferase 3 (Lewis blood group)provided by HGNC
Primary source
HGNC:HGNC:4014
See related
Ensembl:ENSG00000171124 MIM:111100; AllianceGenome:HGNC:4014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LE; Les; FT3B; CD174; FucT-III
Summary
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
Annotation information
Annotation category: suggests misassembly
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more
Orthologs
all
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Genomic context

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See FUT3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5842888..5857122, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5830330..5844569, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5842899..5857133, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene fucosyltransferase 6 Neighboring gene uncharacterized LOC101928844 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5855126-5855513 Neighboring gene Sharpr-MPRA regulatory region 2774 Neighboring gene Sharpr-MPRA regulatory region 10376 Neighboring gene fucosyltransferase 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5892267-5893073 Neighboring gene MPRA-validated peak3300 silencer Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene Sharpr-MPRA regulatory region 9916

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of the manganese ion on human alpha3/4 fucosyltransferase III activity. Palma AS, et al. Biometals, 2004 Feb. PMID 14977360
  2. Significance of each of three missense mutations, G484A, G667A, and G808A, present in an inactive allele of the human Lewis gene (FUT3) for alpha(1,3/1,4)fucosyltransferase inactivation. Pang H, et al. Glycoconj J, 1998 Oct. PMID 10211701
  3. [Association of inflammatory bowel disease with the polymorphisms and haplotypes of fucosyltransferase 3 gene]. Guo M, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2015 Dec. PMID 26663064
  4. Fut3 role in breast invasive ductal carcinoma: Investigating its gene promoter and protein expression. do Nascimento JC, et al. Exp Mol Pathol, 2015 Dec. PMID 26321244
  5. Blood Groups in Infection and Host Susceptibility. Cooling L. Clin Microbiol Rev, 2015 Jul. PMID 26085552, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection.
    Title: Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection.
  2. FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-kappaB pathway.
    Title: FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.
  3. Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
    Title: Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
  4. Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
    Title: Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
  5. Correlations of FUT3 gene polymorphisms with colon polyps.
    Title: Correlations of FUT3 gene polymorphisms with colon polyps.
  6. Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
    Title: Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
  7. Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
    Title: Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
  8. Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
    Title: Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
  9. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
    Title: FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
  10. High FUT3 expression is a marker of lower overall survival of breast cancer patients.
    Title: High FUT3 expression is a marker of lower overall survival of breast cancer patients.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Blood group, lewis system
MedGen: C0023595 OMIM: 618983 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
EBI GWAS Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131739

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity TAS
Traceable Author Statement
more info
  
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
  
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell recognition IC
Inferred by Curator
more info
 PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macromolecule glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Names
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
Lewis FT
alpha-(1,3/1,4)-fucosyltransferase
alpha-3-fucosyltransferase FUT3
blood group Lewis alpha-4-fucosyltransferase
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
fucosyltransferase III
galactoside 3(4)-L-fucosyltransferase
NP_000140.1
NP_001091108.3
NP_001091109.3
NP_001091110.3
NP_001361669.1
NP_001369673.1
NP_001369674.1
NP_001369675.1
NP_001369676.1
NP_001369677.1
NP_001369678.1
NP_001369679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007482.2 RefSeqGene

    Range
    10674..19235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_800

mRNA and Protein(s)

  1. NM_000149.4 → NP_000140.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    See identical proteins and their annotated locations for NP_000140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as minor I, represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000305603.5, ENST00000303225.12
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. NM_001097639.3 → NP_001091108.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as major II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000465804.1, ENST00000589620.6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. NM_001097640.3 → NP_001091109.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as major I, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000468123.1, ENST00000589918.5
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  4. NM_001097641.3 → NP_001091110.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as minor II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Related
    ENSP00000416443.1, ENST00000458379.7
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  5. NM_001374740.1 → NP_001361669.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  6. NM_001382744.1 → NP_001369673.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  7. NM_001382745.1 → NP_001369674.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  8. NM_001382746.1 → NP_001369675.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  9. NM_001382747.1 → NP_001369676.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    AC024592, U27328
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  10. NM_001382748.2 → NP_001369677.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  11. NM_001382749.2 → NP_001369678.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  12. NM_001382750.2 → NP_001369679.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

    Status: REVIEWED

    Source sequence(s)
    NTIA01000094
    Consensus CDS
    CCDS12153.1
    UniProtKB/TrEMBL
    A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
    Conserved Domains (2) summary
    pfam00852
    Location:189 → 357
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:60 → 170
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    5842888..5857122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791810.1 Reference GRCh38.p14 PATCHES

    Range
    16467..30706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    5830330..5844569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21217.2 GenPept UniProtKB/Swiss-Prot:P21217

Gene LinkOut

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