Syk spleen associated tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25155, updated on 2-Nov-2024

Summary

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Official Symbol: Sykprovided by RGD
Official Full Name: spleen associated tyrosine kinaseprovided by RGD
Primary source: RGD:3796
See related: EnsemblRapid:ENSRNOG00000012160 AllianceGenome:RGD:3796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p72syk
Summary: Enables protein domain specific binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of mast cell degranulation; protein autophosphorylation; and regulation of immune response. Predicted to be located in early phagosome and nucleus. Predicted to be part of B cell receptor complex and T cell receptor complex. Predicted to be active in plasma membrane. Used to study anti-basement membrane glomerulonephritis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 486.2), Thymus (RPKM 76.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Syk in Genome Data Viewer

Location:: 17p14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (12756493..12830927, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (12604615..12678437, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (12614311..12669568, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was demonstrated in the present study that Syk was markedly activated in the development of Diabetic cardiomyopathy, subsequently promoting NLRP3 inflammasome activation through the phosphorylation of JNK, leading to the cleavage of pro-caspase-1 and maturation of IL-1beta, and finally contributing to diabetic cardiac dysfunction.
Title: Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex.
Title: Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
present results determined that high glucoseinduced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL1beta and mature IL1beta. The present study identified that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in the pathogenesis ofdiabetic nephropathy.
Title: Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.
Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells.
Title: Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.
Brain Syk expression is upregulated after subarachnoid hemorrhage.
Title: Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats.
The results obtained in simulated microgravity show that ROS production in macrophages is a highly gravisensitive process, caused by a diminished Syk phosphorylation.
Title: Syk phosphorylation - a gravisensitive step in macrophage signalling.
Identify role for Syk in acute renal allograft rejection which is independent of T-cell activation.
Title: Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat.
Syk is critical for Dectin-1-mediated activation of mast cells, although the signaling differs from that triggered by FcRI activation
Title: Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.
expressed and activated in antiglomerular basement membrane disease
Title: Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.
Syk is present in neurons of different structures including the cerebellum, the hippocampus, the visual system and the olfactory system; Syk connects immunoreceptors to downstream adaptor/effector molecules in these neurons.
Title: Syk kinase is phosphorylated in specific areas of the developing nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mx1 (e-PCR), detects polymorphism
- UniSTS:143937

RH94716 (e-PCR)
- UniSTS:119963

RH137235 (e-PCR)
- UniSTS:219323

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables Toll-like receptor binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables interleukin-15 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-15 receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in beta selection	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within beta selection	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lectin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to molecule of fungal origin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to molecule of fungal origin	ISS Inferred from Sequence or Structural Similarity more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-3-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-3-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lymph vessel development	IEA Inferred from Electronic Annotation more info
involved_in lymph vessel development	ISO Inferred from Sequence Orthology more info
involved_in lymph vessel development	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune system process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-3 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of interleukin-3 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of arachidonate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil degranulation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in serotonin secretion by platelet	IEA Inferred from Electronic Annotation more info
involved_in serotonin secretion by platelet	ISO Inferred from Sequence Orthology more info
involved_in serotonin secretion by platelet	ISS Inferred from Sequence or Structural Similarity more info
involved_in stimulatory C-type lectin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of B cell receptor complex	IEA Inferred from Electronic Annotation more info
part_of B cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of T cell receptor complex	IEA Inferred from Electronic Annotation more info
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early phagosome	IEA Inferred from Electronic Annotation more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase SYK

Names: spleen tyrosine kinase

NP_036890.2

EC 2.7.10.2

XP_038951303.1

EC 2.7.10.2

XP_038951304.1

EC 2.7.10.2

XP_038951305.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012758.2 → NP_036890.2 tyrosine-protein kinase SYK

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q64725

UniProtKB/TrEMBL

A6J6S3, G3V7N4

Related

ENSRNOP00000016942.3, ENSRNOT00000016942.8

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

12756493..12830927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095375.2 → XP_038951303.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

Q64725

UniProtKB/TrEMBL

A6J6S3, G3V7N4

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_039095377.2 → XP_038951305.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

Q64725

UniProtKB/TrEMBL

A6J6S3, G3V7N4

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_039095376.2 → XP_038951304.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/Swiss-Prot

Q64725

UniProtKB/TrEMBL

A6J6S3, G3V7N4

Conserved Domains (3) summary

cd05116
Location:370 → 625

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:12 → 115

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:163 → 261

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins