Adm adrenomedullin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Admprovided by RGD
Official Full Name: adrenomedullinprovided by RGD
Primary source: RGD:2047
See related: AllianceGenome:RGD:2047
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ap; RATAP; H39316
Summary: Enables adrenomedullin receptor binding activity. Involved in several processes, including androgen metabolic process; regulation of heart contraction; and response to insulin. Located in extracellular space. Used to study congestive heart failure and toxic shock syndrome. Biomarker of glomerulonephritis; hypertension; hypertrophic cardiomyopathy; obstructive jaundice; and ureteral obstruction. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 36.0), Heart (RPKM 25.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (174164178..174182372)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164745484..164747655)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (175443189..175447260)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Title: Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
MicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury.
Title: MicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury.
results suggest that the increased Adrenomedullin bioactivity induced mechanical allodynia.
Title: Intrathecal administration of adrenomedullin induces mechanical allodynia and neurochemical changes in spinal cord and DRG.
Study suggests that the increased adrenomedullin receptor signaling mediated the many, but not all, tumor necrosis factor-alpha-induced activities, contributing to peripheral sensitization in neuropathic pain.
Title: Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in rats.
Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP.
Title: Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
Levels of adrenomedullin peptide fragments respond to pulmonary remodeling in pulmonary hypertension.
Title: Expression of peptide fragments from proADM and involvement of mitogen-activated protein kinase signaling pathways in pulmonary remodeling induced by high pulmonary blood flow.
Findings demonstrate a dysregulation of cerebellar adrenomedullin-system during hypertension, and suggest that cerebellar drenomedullin plays an important role in the regulation of blood pressure.
Title: Role of cerebellar adrenomedullin in blood pressure regulation.
AM/AMBP-1 accelerated wound healing by promoting angiogenesis, collagen deposition and remodeling
Title: Combination of adrenomedullin with its binding protein accelerates cutaneous wound healing.
Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2).
Title: Adrenomedullin promotes rat trophoblast stem cell differentiation.
Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.
Title: Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adrenomedullin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables adrenomedullin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables adrenomedullin receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenomedullin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenomedullin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in response to ether	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spongiotrophoblast layer development	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-adrenomedullin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012715.2 → NP_036847.1 pro-adrenomedullin precursor

See identical proteins and their annotated locations for NP_036847.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P43145

UniProtKB/TrEMBL

A6I816

Conserved Domains (1) summary

pfam00214
Location:2 → 148

Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

174164178..174182372

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281152.1 → XP_063137222.1 pro-adrenomedullin isoform X1

UniProtKB/Swiss-Prot

P43145

UniProtKB/TrEMBL

A6I816
XM_063281156.1 → XP_063137226.1 pro-adrenomedullin isoform X1

UniProtKB/Swiss-Prot

P43145

UniProtKB/TrEMBL

A6I816