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Fgfr2 fibroblast growth factor receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25022, updated on 28-Oct-2024

Summary

Official Symbol
Fgfr2provided by RGD
Official Full Name
fibroblast growth factor receptor 2provided by RGD
Primary source
RGD:2611
See related
EnsemblRapid:ENSRNOG00000016374 AllianceGenome:RGD:2611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KGFR
Summary
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in several processes, including cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and positive regulation of vascular associated smooth muscle cell proliferation. Located in cell surface. Used to study prostate cancer and retinitis pigmentosa. Biomarker of essential hypertension; hypospadias; portal hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 150.3), Lung (RPKM 131.4) and 9 other tissues See more
Orthologs
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Genomic context

See Fgfr2 in Genome Data Viewer
Location:
1q37
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194175703..194280914, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (184745418..184850655, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (200590951..200696946, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555965 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC100911081 Neighboring gene protein UXT-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branch elongation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bud elongation involved in lung branching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within coronal suture morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within digestive tract development ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in endochondral bone growth IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within endodermal digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermis morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lacrimal gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lateral sprouting from an epithelium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens fiber cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung lobe morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung-associated mesenchyme development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within membranous septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell differentiation involved in lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within morphogenesis of embryonic epithelium ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in orbitofrontal cortex development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within otic vesicle formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of urothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate epithelial cord elongation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of morphogenesis of a branching structure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reproductive structure development ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of urothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular zone neuroblast division ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fibroblast growth factor receptor 2
NP_001103362.1
NP_001103363.1
NP_001103364.1
NP_001103365.1
NP_001103366.1
NP_036844.1
XP_006230451.1
XP_006230452.1
XP_006230455.1
XP_063137142.1
XP_063137143.1
XP_063137147.1
XP_063137148.1
XP_063137149.1
XP_063137153.1
XP_063137154.1
XP_063137155.1
XP_063137158.1
XP_063137162.1
XP_063137164.1
XP_063137168.1
XP_063137169.1
XP_063137170.1
XP_063137171.1
XP_063137182.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109892.1NP_001103362.1  fibroblast growth factor receptor 2 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate internal exon and contains an alternate internal exon compared to variant a. The resulting isoform (b) has the same N- and C-termini but differs in an internal segment compared to isoform a.
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19105, L19110
    UniProtKB/TrEMBL
    F1LNW0
    Related
    ENSRNOP00000022253.4, ENSRNOT00000022253.8
    Conserved Domains (6) summary
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    cd05101
    Location:475787
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:500776
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:66143
    Ig; Immunoglobulin domain
  2. NM_001109893.1NP_001103363.1  fibroblast growth factor receptor 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks an alternate in-frame exon compared to variant a. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19107, L19110
    UniProtKB/TrEMBL
    F1LRU8
    Related
    ENSRNOP00000061479.1, ENSRNOT00000065448.5
    Conserved Domains (5) summary
    cd04974
    Location:201288
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:94178
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:193287
    IG_like; Immunoglobulin like
    cd05101
    Location:387699
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:412688
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001109894.1NP_001103364.1  fibroblast growth factor receptor 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) lacks an alternate in-frame exon, lacks an alternate internal exon, and contains an alternate internal exon compared to variant a. The resulting isoform (d) has the same N- and C-termini but lacks an internal segment and differs in an internal segment compared to isoform a.
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110, L19112
    UniProtKB/TrEMBL
    Q63236, Q63240, Q63242
    Conserved Domains (5) summary
    cd05857
    Location:94178
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:201290
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:193289
    IG_like; Immunoglobulin like
    cd05101
    Location:386698
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:411687
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001109895.1NP_001103365.1  fibroblast growth factor receptor 2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks two alternate in-frame exons compared to variant a. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19108, L19110
    UniProtKB/TrEMBL
    F1LN06
    Related
    ENSRNOP00000022331.5, ENSRNOT00000022331.8
    Conserved Domains (5) summary
    cd04974
    Location:175262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:68152
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:167261
    IG_like; Immunoglobulin like
    cd05101
    Location:361673
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:386662
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_001109896.1NP_001103366.1  fibroblast growth factor receptor 2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) lacks two alternate in-frame exons, lacks an alternate internal exon, and contains an alternate internal exon compared to variant a. The resulting isoform (f) has the same N- and C-termini but lacks an internal segment and differs in an internal segment compared to isoform a.
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110, L19111, L19112
    UniProtKB/TrEMBL
    Q63236, Q63240, Q63241, Q63242
    Conserved Domains (5) summary
    cd05857
    Location:68152
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:175264
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:167263
    IG_like; Immunoglobulin like
    cd05101
    Location:360672
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:385661
    Pkinase_Tyr; Protein tyrosine kinase
  6. NM_012712.1NP_036844.1  fibroblast growth factor receptor 2 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AW531062, BF420170, CB716134, CB769194, CB777398, CB780941, CF109832, CO397781, DV718561, L19104, L19110
    UniProtKB/TrEMBL
    F1LSG7
    Related
    ENSRNOP00000059005.1, ENSRNOT00000068183.4
    Conserved Domains (5) summary
    cd05101
    Location:476788
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275377
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    194175703..194280914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230393.5XP_006230455.1  fibroblast growth factor receptor 2 isoform X13

    Conserved Domains (5) summary
    cd05857
    Location:68152
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:175264
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:167263
    IG_like; Immunoglobulin like
    cd05101
    Location:358670
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:383659
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_063281101.1XP_063137171.1  fibroblast growth factor receptor 2 isoform X12

  3. XM_063281100.1XP_063137170.1  fibroblast growth factor receptor 2 isoform X11

    UniProtKB/TrEMBL
    F1LN06
  4. XM_063281099.1XP_063137169.1  fibroblast growth factor receptor 2 isoform X10

  5. XM_063281098.1XP_063137168.1  fibroblast growth factor receptor 2 isoform X9

  6. XM_063281092.1XP_063137162.1  fibroblast growth factor receptor 2 isoform X8

    UniProtKB/TrEMBL
    F1LRU8
  7. XM_006230390.5XP_006230452.1  fibroblast growth factor receptor 2 isoform X4

    Conserved Domains (6) summary
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    cd05101
    Location:473785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:498774
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:66143
    Ig; Immunoglobulin domain
  8. XM_063281085.1XP_063137155.1  fibroblast growth factor receptor 2 isoform X6

  9. XM_063281079.1XP_063137149.1  fibroblast growth factor receptor 2 isoform X2

    UniProtKB/TrEMBL
    F1LNW0
  10. XM_006230389.5XP_006230451.1  fibroblast growth factor receptor 2 isoform X3

    Conserved Domains (6) summary
    cd04974
    Location:290377
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:282376
    IG_like; Immunoglobulin like
    cd05101
    Location:474786
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:499775
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:66143
    Ig; Immunoglobulin domain
  11. XM_063281072.1XP_063137142.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    F1LSG7
  12. XM_063281084.1XP_063137154.1  fibroblast growth factor receptor 2 isoform X5

  13. XM_063281078.1XP_063137148.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    F1LSG7
  14. XM_063281077.1XP_063137147.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    F1LSG7
  15. XM_063281112.1XP_063137182.1  fibroblast growth factor receptor 2 isoform X14

  16. XM_063281094.1XP_063137164.1  fibroblast growth factor receptor 2 isoform X8

    UniProtKB/TrEMBL
    F1LRU8
  17. XM_063281083.1XP_063137153.1  fibroblast growth factor receptor 2 isoform X4

  18. XM_063281073.1XP_063137143.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    F1LSG7
  19. XM_063281088.1XP_063137158.1  fibroblast growth factor receptor 2 isoform X7