Vsnl1 visinin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vsnl1provided by RGD
Official Full Name: visinin-like 1provided by RGD
Primary source: RGD:3966
See related: EnsemblRapid:ENSRNOG00000005345 AllianceGenome:RGD:3966
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nvp1; Ratnvp1
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in calcium-mediated signaling and central nervous system development. Predicted to act upstream of or within negative regulation of insulin secretion; positive regulation of exocytosis; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol and membrane. Orthologous to human VSNL1 (visinin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 978.7), Adrenal (RPKM 154.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 6q15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (39757721..39878556, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (34038641..34159479, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (37001360..37121969, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Vsnl1 in the rat adrenal gland or adrenocortical cells was acutely down regulated by ACTH, while chronic administration of corticotrophin or dexamethasone did not change Vsnl1 mRNA levels.
Title: Visinin-like peptide 1 in adrenal gland of the rat. Gene expression and its hormonal control.
This study demonistrated that Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.
Title: Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.
In dissociated rat hippocampal neurons, VILIP-1 small interfering RNA knockdown decreases cyclic AMP levels and reduces dendrite branching, compared with control-transfected cells. In contrast, VILIP-1 overexpression has the opposite effect.
Title: Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology.
Results show that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B.
Title: Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart.
In rat brain VILIP-1 and alpha4beta2 nicotinic receptor show partial co-localization in the hippocampal CA1 region and dentate gyrus.
Title: Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia.
VILIP-1 might provide a novel functional crosstalk between alpha4- and alpha7-containing nAChRs.
Title: Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for nicotinic receptors.
VILIP-1 is strongly expressed in different populations of principal and non-principal neurons in the rat hippocampus. VILIP-1-containing interneurons are morphologically and neurochemically heterogeneous.
Title: Expression of the neuronal calcium sensor visinin-like protein-1 in the rat hippocampus.
These results suggest that alsin binds cell membrane in a Ca(2+)-dependent manner through NCalpha and regulates membrane dynamics.
Title: Molecular interaction of neurocalcin alpha with alsin (ALS2).
the inhibitory glycine receptor is localized to hippocampal neurons
Title: Cellular and subcellular localization of the inhibitory glycine receptor in hippocampal neurons.
direct comparison of the localization and calcium-dependent translocation of visinin-like-proteins 1 and 3 in hippocampal neurons
Title: Calcium-myristoyl switch, subcellular localization, and calcium-dependent translocation of the neuronal calcium sensor protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80046 (e-PCR)
- UniSTS:83724

D6Got35 (e-PCR)
- UniSTS:114211

d6arb5 (e-PCR)
- UniSTS:122181

D6Arb7 (e-PCR), detects polymorphism
- UniSTS:227972

RH139543 (e-PCR)
- UniSTS:221628

D6Rat38 (e-PCR), detects polymorphism
- UniSTS:228066

RH140383 (e-PCR)
- UniSTS:222459

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: visinin-like protein 1

Names: 21 kDa CABP; NVL-1; NVP-1; VILIP; neural visinin-like protein 1; neurocalcin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012686.2 → NP_036818.2 visinin-like protein 1

See identical proteins and their annotated locations for NP_036818.2

Status: PROVISIONAL

Source sequence(s)

BC092197

UniProtKB/TrEMBL

Q56A29

Related

ENSRNOP00000007609.3, ENSRNOT00000007609.7

Conserved Domains (2) summary

COG5126
Location:15 → 181

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:65 → 125

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...