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Ppcdc Phosphopantothenoylcysteine decarboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246533, updated on 2-Nov-2024

Summary

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Official Symbol
Ppcdcprovided by FlyBase
Official Full Name
Phosphopantothenoylcysteine decarboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0050290
Locus tag
Dmel_CG30290
See related
AllianceGenome:FB:FBgn0050290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD37882; CG30290; Dmel\CG30290; dPPCDC; Dromel_CG30290_FBtr0071672_cx9c_mORF; PPCDC
Summary
Predicted to enable FMN binding activity and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Is expressed in organism. Used to study neurodegeneration with brain iron accumulation. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ppcdc in Genome Data Viewer
Location:
57F8-57F9; 2-96 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21691295..21692764)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17578800..17580269)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Baramicin C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 10 Neighboring gene uncharacterized protein Neighboring gene Cyclic nucleotide-gated ion channel subunit B Neighboring gene HMG protein Z Neighboring gene High mobility group protein D Neighboring gene long non-coding RNA:CR44749

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis. Srinivasan B, et al. Nat Chem Biol, 2015 Oct. PMID 26322826
  2. CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases. Lambrechts RA, et al. EMBO Mol Med, 2019 Dec. PMID 31701655, Free PMC Article
  3. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
  4. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Bosveld F, et al. Hum Mol Genet, 2008 Jul 1. PMID 18407920
  5. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism. Huang Y, et al. Nat Commun, 2022 May 3. PMID 35504872, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantothenoylcysteine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopantothenoylcysteine decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of phosphopantothenoylcysteine decarboxylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphopantothenoylcysteine decarboxylase
Names
(R)-4'-phospho-N-pantothenoylcysteine decarboxylase
CG30290-PA
CG30290-PB
Ppcdc-PA
Ppcdc-PB
NP_001286691.1
NP_726105.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21691295..21692764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299762.1 → NP_001286691.1  phosphopantothenoylcysteine decarboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MKK3
    Conserved Domains (1) summary
    cl19190
    Location:7 → 187
    Flavoprotein; Flavoprotein

  2. NM_166475.3 → NP_726105.1  phosphopantothenoylcysteine decarboxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726105.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MKK3
    Related
    FBpp0071589
    Conserved Domains (1) summary
    cl19190
    Location:7 → 187
    Flavoprotein; Flavoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MKK3 Q8MKK3

Gene LinkOut

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