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Fst follistatin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24373, updated on 2-Nov-2024

Summary

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Symbol
Fstprovided by RGD
Full Name
follistatinprovided by RGD
Primary source
RGD:2633
See related
EnsemblRapid:ENSRNOG00000011631 AllianceGenome:RGD:2633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FS; FOL1; Fst-288; RATFOL1
Summary
Enables heparan sulfate proteoglycan binding activity. Involved in cellular response to growth factor stimulus and response to organic cyclic compound. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 36.4), Muscle (RPKM 32.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fst in Genome Data Viewer
Location:
2q14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (47856345..47863670, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (46123260..46130584, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46537589..46544813, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 15 Neighboring gene uncharacterized LOC120100716 Neighboring gene transfer RNA threonine (anticodon AGU) 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene uncharacterized LOC120100717 Neighboring gene uncharacterized LOC103691459 Neighboring gene developmental pluripotency-associated protein 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Follistatin expression in the central nervous system of the adult rat. Ogawa C, et al. J Chem Neuroanat, 2020 Apr. PMID 32014555
  2. Follistatin gene expression in the ovary and extragonadal tissues. Shimasaki S, et al. Mol Endocrinol, 1989 Apr. PMID 2725528
  3. Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter. Miyanaga K, et al. Mol Cell Endocrinol, 1993 Mar. PMID 8472873
  4. Dynamics of messenger RNAs encoding inhibin/activin subunits and follistatin in the ovary during the rat estrous cycle. Arai KY, et al. Biol Reprod, 2002 Apr. PMID 11906933
  5. Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells. Fujii Y, et al. Mol Cell Endocrinol, 2002 Jun 28. PMID 12088867

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
    Title: Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
  2. Follistatin expression in the central nervous system of the adult rat.
    Title: Follistatin expression in the central nervous system of the adult rat.
  3. These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance.
    Title: Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance.
  4. manifestation of polycystic ovarian syndrome-like phenotype following prenatal exposure to excess androgen is associated with irregularity in expression of the FST gene during the estrus cycle
    Title: Alteration in follistatin gene expression detected in prenatally androgenized rats.
  5. Results show that Myostatin and follistatin protein expression is reduced in the long-term hypertrophied myocardium from spontaneously hypertensive rats with heart failure.
    Title: Myocardial myostatin in spontaneously hypertensive rats with heart failure.
  6. Myogenin, myostatin, and follistatin expression is lower and myogenic regulatory factor (MRF)4 levels higher in spontaneously hypertensive rats (SHR) with heart failure compared to the Wistar-Kyoto strain.
    Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
  7. Expression of follistatin and myostatin mRNA is increased in muscle and subcutaneous fat of sedentary diabetic rats compared with sedentary control rats.
    Title: Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise.
  8. The ratio of follistatin/myostatin could be used to monitor the progress of target muscle atrophy and recovery.
    Title: A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood.
  9. Fst expression is necessary for the proliferation of small hepatocytes.
    Title: Proliferation of rat small hepatocytes requires follistatin expression.
  10. Effects of training and androgens on MYOPRO and FOLLI concentrations in blood and skeletal muscle, were investigated.
    Title: Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin binding ISO
Inferred from Sequence Orthology
more info
  
enables activin binding TAS
Traceable Author Statement
more info
 PubMed 
enables activin receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
  
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of ameloblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
follistatin
Names
activin-binding protein
follistatin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012561.4 → NP_036693.1  follistatin precursor

    See identical proteins and their annotated locations for NP_036693.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P21674, Q80XW7
    Related
    ENSRNOP00000015680.1, ENSRNOT00000015680.6
    Conserved Domains (2) summary
    smart00274
    Location:94 → 117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117 → 164
    KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    47856345..47863670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231953.5 → XP_006232015.1  follistatin isoform X1

    Conserved Domains (2) summary
    smart00274
    Location:94 → 117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117 → 164
    KAZAL; Kazal type serine protease inhibitors

  2. XM_006231954.5 → XP_006232016.1  follistatin isoform X2

    Conserved Domains (2) summary
    smart00274
    Location:94 → 117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117 → 164
    KAZAL; Kazal type serine protease inhibitors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21674.1 GenPept UniProtKB/Swiss-Prot:P21674

Gene LinkOut

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