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Ddc dopa decarboxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24311, updated on 2-Nov-2024

Summary

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Official Symbol
Ddcprovided by RGD
Official Full Name
dopa decarboxylaseprovided by RGD
Primary source
RGD:2494
See related
EnsemblRapid:ENSRNOG00000004327 AllianceGenome:RGD:2494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AADC
Summary
Enables several functions, including amino acid binding activity; aromatic-L-amino-acid decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; dopamine biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 88.8), Heart (RPKM 51.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddc in Genome Data Viewer
Location:
14q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90592304..90682830, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86378685..86469189, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91905919..91996816, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 1 Neighboring gene uncharacterized LOC120096666 Neighboring gene fidgetin-like 1 Neighboring gene uncharacterized LOC120096667 Neighboring gene growth factor receptor bound protein 10 Neighboring gene uncharacterized LOC102552764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Acid-base chemistry of the reaction of aromatic L-amino acid decarboxylase and dopa analyzed by transient and steady-state kinetics: preferential binding of the substrate with its amino group unprotonated. Hayashi H, et al. Biochemistry, 1999 Nov 23. PMID 10569946
  2. DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms. Seo DC, et al. Int J Mol Sci, 2023 Jan 27. PMID 36768816, Free PMC Article
  3. Blunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome. Sampaio-Maia B, et al. Nephrol Dial Transplant, 2006 Feb. PMID 16204272
  4. Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats. Ershov PV, et al. J Chem Neuroanat, 2005 Jul. PMID 15935614
  5. The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study. Foster SB, et al. Chem Res Toxicol, 2003 Oct. PMID 14565778

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
    Title: DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.
  2. The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.
    Title: Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.
  3. The expression of striatal L: -amino-acid decarboxylase (AADC) in L: -DOPA-induced dyskinesia rats, even though tyrosine hydroxylase (TH) expression did not increase.
    Title: The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model.
  4. AADC in the SCN is expressed in clock oscillating cells, and the decarboxylating activity of master clock cells are under the control of the circadian rhythm
    Title: Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells.
  5. 1-methyl-4-phenylpyridinium caused rapid inhibition of DDC, which appears to result in intraneuronal accumulation and subsequent release of l-DOPA
    Title: The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93628

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5-hydroxy-L-tryptophan decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5-hydroxy-L-tryptophan decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-dopa decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-dopa decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatic-L-amino-acid decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatic-L-amino-acid decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatic-L-amino-acid decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in catecholamine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in catecholamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to alkaloid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dopamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dopamine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in isoquinoline alkaloid metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in phytoalexin metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to pyrethroid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in serotonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aromatic-L-amino-acid decarboxylase
Names
L-Dopa decarboxylase
dopa decarboxylase (aromatic L-amino acid decarboxylase)
NP_001257781.1
NP_001257782.1
NP_036677.1
XP_008768475.3
XP_063128928.1
XP_063128929.1
XP_063128930.1
XP_063128931.1
XP_063128932.1
XP_063128933.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270852.1 → NP_001257781.1  aromatic-L-amino-acid decarboxylase isoform a

    See identical proteins and their annotated locations for NP_001257781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    JAXUCZ010000014, M27716
    UniProtKB/Swiss-Prot
    P14173, Q6LEG4
    UniProtKB/TrEMBL
    A0A8L2QX98, A6KJB5
    Related
    ENSRNOP00000082788.1, ENSRNOT00000103628.2
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. NM_001270853.1 → NP_001257782.1  aromatic-L-amino-acid decarboxylase isoform b

    See identical proteins and their annotated locations for NP_001257782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    JAXUCZ010000014, JF273828, M27716
    UniProtKB/TrEMBL
    A0A8J8YSU9, D3ZMA5, F8TLS6
    Related
    ENSRNOP00000053885.5, ENSRNOT00000057051.6
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 374
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  3. NM_012545.4 → NP_036677.1  aromatic-L-amino-acid decarboxylase isoform a

    See identical proteins and their annotated locations for NP_036677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    JAXUCZ010000014, M27716
    UniProtKB/Swiss-Prot
    P14173, Q6LEG4
    UniProtKB/TrEMBL
    A0A8L2QX98, A6KJB5
    Related
    ENSRNOP00000005851.4, ENSRNOT00000005851.8
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    90592304..90682830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272858.1 → XP_063128928.1  aromatic-L-amino-acid decarboxylase isoform X1

  2. XM_008770253.4 → XP_008768475.3  aromatic-L-amino-acid decarboxylase isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZZE6
    Related
    ENSRNOP00000085523.1, ENSRNOT00000093904.2

  3. XM_063272862.1 → XP_063128932.1  aromatic-L-amino-acid decarboxylase isoform X4

    UniProtKB/Swiss-Prot
    P14173, Q6LEG4
    UniProtKB/TrEMBL
    A6KJB5

  4. XM_063272860.1 → XP_063128930.1  aromatic-L-amino-acid decarboxylase isoform X3

  5. XM_063272861.1 → XP_063128931.1  aromatic-L-amino-acid decarboxylase isoform X3

  6. XM_063272859.1 → XP_063128929.1  aromatic-L-amino-acid decarboxylase isoform X2

  7. XM_063272863.1 → XP_063128933.1  aromatic-L-amino-acid decarboxylase isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14173.1 GenPept UniProtKB/Swiss-Prot:P14173

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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