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UL27 envelope glycoprotein B [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 24271469, updated on 31-Jan-2024

Summary

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Gene symbol
UL27
Gene description
envelope glycoprotein B
Locus tag
HHV1gp00p48
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (53059..55795, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene involved in nucleotide metabolism Neighboring gene nuclear protein UL24 Neighboring gene DNA packaging tegument protein UL25 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein Neighboring gene DNA packaging terminase subunit 2 Neighboring gene single-stranded DNA-binding protein Neighboring gene DNA polymerase catalytic subunit Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells. Treat BR, et al. PLoS Pathog, 2017 Dec. PMID 29206240, Free PMC Article
  2. Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype. Fan Q, et al. mBio, 2017 May 16. PMID 28512095, Free PMC Article
  3. Role of Herpes Simplex Envelope Glycoprotein B and Toll-Like Receptor 2 in Ocular Inflammation: An ex vivo Organotypic Rabbit Corneal Model. Marino A, et al. Viruses, 2019 Sep 4. PMID 31487910, Free PMC Article
  4. Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor. Furukawa A, et al. J Biol Chem, 2017 Dec 22. PMID 29046357, Free PMC Article
  5. The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes. Musarrat F, et al. J Virol, 2018 Mar 15. PMID 29321326, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Herpes Simplex Envelope Glycoprotein B and Toll-Like Receptor 2 in Ocular Inflammation: An ex vivo Organotypic Rabbit Corneal Model.
    Title: Role of Herpes Simplex Envelope Glycoprotein B and Toll-Like Receptor 2 in Ocular Inflammation: An ex vivo Organotypic Rabbit Corneal Model.
  2. Data suggest that, although PILRA exhibits essentially the same recognition of different glycopeptides, slight modifications of linker sugar cause significant changes in a wide area of the binding interface, resulting in a reduction of binding affinity; analogs/fragments of gpb were used in these studies. (PILRA = paired immunoglobin like type 2 receptor alpha; gpb = envelope glycoprotein B, Herpes simplex virus type 1)
    Title: Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor.
  3. a deletion in the amino terminus of glycoprotein K (gK) inhibits gB binding to Akt-1(S473), the release of intracellular calcium, and virus entry via fusion of the viral envelope with cellular plasma membranes.
    Title: The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes.
  4. study supports our hypothesis that an interaction between the gB arm and the core of gB is critical for gB refolding and the execution of membrane fusion, thus providing key details about the function of gB in herpesvirus-mediated fusion and subsequent virus entry
    Title: Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.
  5. Data suggest that loss of immunodominant gB498-505 epitope from glycoprotein B alters dominance hierarchy and reduces functional compromise of CD8+ T-cells specific for subdominant HSV-1 epitopes during viral latency. Some of these studies were conducted in cultures of CD8+ T-cells from latently infected trigeminal ganglia of C57BL/6 mice following corneal infection with recombinant HSV-1 lacking gB498-505 epitope.
    Title: Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.
Submit: New GeneRIF Correction

General gene information

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Homology

regulatory

  • Loc: c53064-53059 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
envelope glycoprotein B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    53059..55795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137102.1 envelope glycoprotein B [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137102.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQF5, P10211, Q09IA6
    UniProtKB/TrEMBL
    A0A181ZFT6, A0A181ZGI5, A0A181ZH10, A0A1C3J7G1, A0A2U9A6P1, A0A2Z4HBK2, A0A5P8I1E4, F8RFB2
    Conserved Domains (1) summary
    PHA03231
    Location:83 → 900
    PHA03231; glycoprotein BALF4; Provisional
Nucleotide Protein
Heading Accession and Version

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