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Actbl2 actin, beta-like 2 [ Mus musculus (house mouse) ]

Gene ID: 238880, updated on 2-Nov-2024

Summary

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Official Symbol
Actbl2provided by MGI
Official Full Name
actin, beta-like 2provided by MGI
Primary source
MGI:MGI:2444552
See related
Ensembl:ENSMUSG00000055194 AllianceGenome:MGI:2444552
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732495G21Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Is active in glutamatergic synapse. Orthologous to human ACTBL2 (actin beta like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Actbl2 in Genome Data Viewer
Location:
13 D2.2; 13 63.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111391547..111394283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111255013..111257749)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene RIKEN cDNA 3110015C05 gene Neighboring gene STARR-seq mESC enhancer starr_35651 Neighboring gene electron transfer flavoprotein subunit alpha, mitochondrial pseudogene Neighboring gene GC-rich promoter binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2421 Neighboring gene STARR-positive B cell enhancer ABC_E1468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. Zhang D, et al. CNS Neurosci Ther, 2023 Oct. PMID 37072933, Free PMC Article
  2. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
  3. PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. Illingworth RS, et al. PLoS One, 2012. PMID 22496869, Free PMC Article
  4. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
  5. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of postsynaptic actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
beta-actin-like protein 2
Names
kappa-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175497.3 → NP_780706.1  beta-actin-like protein 2

    See identical proteins and their annotated locations for NP_780706.1

    Status: PROVISIONAL

    Source sequence(s)
    AK029110
    Consensus CDS
    CCDS26768.1
    UniProtKB/Swiss-Prot
    Q8BFZ3
    UniProtKB/TrEMBL
    Q3U5R4, Q3UA89, Q3UAF7, Q3UGS0, Q61276
    Related
    ENSMUSP00000052086.4, ENSMUST00000054716.4
    Conserved Domains (2) summary
    smart00268
    Location:7 → 376
    ACTIN; Actin
    cl17037
    Location:1 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    111391547..111394283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFZ3.1 GenPept UniProtKB/Swiss-Prot:Q8BFZ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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