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CDK20 cyclin dependent kinase 20 [ Homo sapiens (human) ]

Gene ID: 23552, updated on 14-Nov-2024

Summary

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Official Symbol
CDK20provided by HGNC
Official Full Name
cyclin dependent kinase 20provided by HGNC
Primary source
HGNC:HGNC:21420
See related
Ensembl:ENSG00000156345 MIM:610076; AllianceGenome:HGNC:21420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P42; CCRK; CDCH; PNQALRE
Summary
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
Expression
Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues See more
Orthologs
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Genomic context

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See CDK20 in Genome Data Viewer
Location:
9q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87966441..87974533, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (100120474..100128570, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90581356..90589448, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598, E3 ubiquitin ligase pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90566553-90567406 Neighboring gene uncharacterized LOC122394732 Neighboring gene uncharacterized LOC124902200 Neighboring gene uncharacterized LOC105376131 Neighboring gene RNA, U6 small nuclear 86, pseudogene Neighboring gene ribosomal protein S10 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Role of CDK20 Protein in Carcinogenesis. Chivukula S, et al. Curr Drug Targets, 2023. PMID 37469151
  2. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. Wu GQ, et al. Int J Cancer, 2009 Dec 1. PMID 19672860
  3. Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis. An X, et al. Eur J Cancer, 2010 Jun. PMID 20466538
  4. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Wohlbold L, et al. Cell Cycle, 2006 Mar. PMID 16552187
  5. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Zhou J, et al. Gut, 2018 May. PMID 28939663, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of CDK20 Protein in Carcinogenesis.
    Title: The Role of CDK20 Protein in Carcinogenesis.
  2. BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
    Title: BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
  3. Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy
    Title: Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.
  4. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patient.
    Title: A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.
  5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation.
    Title: CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.
  6. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas.
    Title: Functional genomics identifies drivers of medulloblastoma dissemination.
  7. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis
    Title: Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis.
  8. results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb.
    Title: Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis.
  9. Overexpression of CCRK is associated with ovarian carcinoma.
    Title: Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.
  10. Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point.
    Title: The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
  
involved_in floor plate formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cilium IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 20
Names
CAK-kinase p42
CDK-activating kinase p42
cell cycle-related kinase
cell division protein kinase 20
cyclin-dependent protein kinase H
cyclin-kinase-activating kinase p42
NP_001034892.1
NP_001164110.1
NP_001164111.1
NP_036251.2
NP_848519.1
XP_016870050.1
XP_016870051.1
XP_016870052.1
XP_016870053.1
XP_047279074.1
XP_047279075.1
XP_047279076.1
XP_047279077.1
XP_047279078.1
XP_047279080.1
XP_047279081.1
XP_054218535.1
XP_054218536.1
XP_054218537.1
XP_054218538.1
XP_054218539.1
XP_054218540.1
XP_054218541.1
XP_054218542.1
XP_054218543.1
XP_054218544.1
XP_054218545.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039803.3 → NP_001034892.1  cyclin-dependent kinase 20 isoform 3

    See identical proteins and their annotated locations for NP_001034892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate, in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI479563, AL353572, BM982394
    Consensus CDS
    CCDS35060.1
    UniProtKB/Swiss-Prot
    A2A389, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q8IZL9, Q9BUF4
    UniProtKB/TrEMBL
    A0A0S2Z557
    Related
    ENSP00000322343.8, ENST00000325303.9
    Conserved Domains (2) summary
    PLN00009
    Location:1 → 288
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3 → 289
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

  2. NM_001170639.2 → NP_001164110.1  cyclin-dependent kinase 20 isoform 4

    See identical proteins and their annotated locations for NP_001164110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BC002655, BM982394, CB992644
    Consensus CDS
    CCDS65075.1
    UniProtKB/TrEMBL
    A0A0S2Z566, A0A0S2Z5B6
    Related
    ENSP00000474485.1, ENST00000605159.5
    Conserved Domains (1) summary
    cd07832
    Location:3 → 273
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

  3. NM_001170640.2 → NP_001164111.1  cyclin-dependent kinase 20 isoform 5

    See identical proteins and their annotated locations for NP_001164111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 5, also known as cardiac CCRK), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
    Consensus CDS
    CCDS55324.1
    UniProtKB/TrEMBL
    A0A0S2Z535
    Related
    ENSP00000365031.3, ENST00000375871.8
    Conserved Domains (2) summary
    smart00220
    Location:4 → 167
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:3 → 167
    PKc_like; Protein Kinases, catalytic domain

  4. NM_012119.5 → NP_036251.2  cyclin-dependent kinase 20 isoform 2

    See identical proteins and their annotated locations for NP_036251.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
    Consensus CDS
    CCDS6677.1
    UniProtKB/TrEMBL
    A0A0S2Z566
    Related
    ENSP00000365043.3, ENST00000375883.7
    Conserved Domains (2) summary
    PLN00009
    Location:1 → 267
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3 → 268
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

  5. NM_178432.4 → NP_848519.1  cyclin-dependent kinase 20 isoform 1

    See identical proteins and their annotated locations for NP_848519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
    Consensus CDS
    CCDS6678.1
    UniProtKB/TrEMBL
    A0A0S2Z566
    Related
    ENSP00000338975.5, ENST00000336654.9
    Conserved Domains (2) summary
    PLN00009
    Location:1 → 280
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3 → 281
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    87966441..87974533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014563.3 → XP_016870052.1  cyclin-dependent kinase 20 isoform X8

  2. XM_017014564.3 → XP_016870053.1  cyclin-dependent kinase 20 isoform X9

    UniProtKB/TrEMBL
    A0A0S2Z562, A0A0S2Z566
    Conserved Domains (2) summary
    PLN00009
    Location:1 → 259
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3 → 260
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

  3. XM_047423121.1 → XP_047279077.1  cyclin-dependent kinase 20 isoform X6

  4. XM_017014561.3 → XP_016870050.1  cyclin-dependent kinase 20 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z557

  5. XM_017014562.3 → XP_016870051.1  cyclin-dependent kinase 20 isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z557

  6. XM_047423124.1 → XP_047279080.1  cyclin-dependent kinase 20 isoform X10

  7. XM_047423122.1 → XP_047279078.1  cyclin-dependent kinase 20 isoform X7

  8. XM_047423119.1 → XP_047279075.1  cyclin-dependent kinase 20 isoform X2

  9. XM_047423118.1 → XP_047279074.1  cyclin-dependent kinase 20 isoform X1

  10. XM_047423120.1 → XP_047279076.1  cyclin-dependent kinase 20 isoform X4

  11. XM_047423125.1 → XP_047279081.1  cyclin-dependent kinase 20 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    100120474..100128570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362567.1 → XP_054218542.1  cyclin-dependent kinase 20 isoform X8

  2. XM_054362568.1 → XP_054218543.1  cyclin-dependent kinase 20 isoform X9

  3. XM_054362565.1 → XP_054218540.1  cyclin-dependent kinase 20 isoform X6

  4. XM_054362562.1 → XP_054218537.1  cyclin-dependent kinase 20 isoform X3

  5. XM_054362564.1 → XP_054218539.1  cyclin-dependent kinase 20 isoform X5

  6. XM_054362569.1 → XP_054218544.1  cyclin-dependent kinase 20 isoform X10

  7. XM_054362566.1 → XP_054218541.1  cyclin-dependent kinase 20 isoform X7

  8. XM_054362561.1 → XP_054218536.1  cyclin-dependent kinase 20 isoform X2

  9. XM_054362560.1 → XP_054218535.1  cyclin-dependent kinase 20 isoform X1

  10. XM_054362563.1 → XP_054218538.1  cyclin-dependent kinase 20 isoform X4

  11. XM_054362570.1 → XP_054218545.1  cyclin-dependent kinase 20 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZL9.1 GenPept UniProtKB/Swiss-Prot:Q8IZL9

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