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Fus fused in sarcoma [ Mus musculus (house mouse) ]

Gene ID: 233908, updated on 14-Nov-2024

Summary

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Official Symbol
Fusprovided by MGI
Official Full Name
fused in sarcomaprovided by MGI
Primary source
MGI:MGI:1353633
See related
Ensembl:ENSMUSG00000030795 AllianceGenome:MGI:1353633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tls; Fus1; D430004D17Rik; D930039C12Rik
Summary
Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is active in several cellular components, including GABA-ergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including branchial arch; central nervous system; eye; genitourinary system; and tooth. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 160.0), CNS E11.5 (RPKM 159.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fus in Genome Data Viewer
Location:
7 F3; 7 69.87 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127565276..127581204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127966789..127982032)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene serine protease 8 (prostasin) Neighboring gene STARR-positive B cell enhancer ABC_E6608 Neighboring gene serine protease 36 Neighboring gene predicted gene, 53375 Neighboring gene STARR-seq mESC enhancer starr_20197 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif-containing 72

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Tan WJT, et al. Antioxid Redox Signal, 2017 Sep 10. PMID 28135838, Free PMC Article
  2. The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation. Reber S, et al. Nucleic Acids Res, 2021 Jul 21. PMID 34233002, Free PMC Article
  3. Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Ishigaki S, et al. Sci Rep, 2012. PMID 22829983, Free PMC Article
  4. Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics. Sugiura T, et al. FEBS J, 2016 Apr. PMID 26896672
  5. Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects. Scekic-Zahirovic J, et al. Nat Commun, 2021 May 21. PMID 34021132, Free PMC Article

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
    Title: Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
  2. FUS reads histone H3K36me3 to regulate alternative polyadenylation.
    Title: FUS reads histone H3K36me3 to regulate alternative polyadenylation.
  3. The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice.
    Title: The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice.
  4. FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
    Title: FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
  5. Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.
    Title: Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.
  6. Aging-disturbed FUS phase transition impairs hematopoietic stem cells by altering chromatin structure.
    Title: Aging-disturbed FUS phase transition impairs hematopoietic stem cells by altering chromatin structure.
  7. CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
    Title: CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
  8. Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
    Title: Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes.
  9. Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition.
    Title: Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition.
  10. LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS.
    Title: LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS.
Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
  
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in membraneless organelle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membraneless organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membraneless organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein FUS
Names
fusion, derived from t(12;16) malignant liposarcoma
hnRNP P2
pigpen protein
protein pigpen
translocated in liposarcoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347649.1 → NP_001334578.1  RNA-binding protein FUS isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC124461
    Consensus CDS
    CCDS85425.1
    UniProtKB/TrEMBL
    Q3UK30, Q8CFQ9
    Related
    ENSMUSP00000076801.6, ENSMUST00000077609.12

  2. NM_139149.2 → NP_631888.1  RNA-binding protein FUS isoform 1

    See identical proteins and their annotated locations for NP_631888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK139960, AK145582, BY269119
    Consensus CDS
    CCDS21886.1
    UniProtKB/Swiss-Prot
    P56959
    UniProtKB/TrEMBL
    Q3UK30, Q564D0
    Related
    ENSMUSP00000101858.4, ENSMUST00000106251.10
    Conserved Domains (3) summary
    COG0724
    Location:257 → 367
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12535
    Location:276 → 361
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:415 → 442
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127565276..127581204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507760.3 → XP_006507823.1  RNA-binding protein FUS isoform X1

    Conserved Domains (2) summary
    cd12535
    Location:71 → 156
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:211 → 237
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_017322218.3 → XP_017177707.1  RNA-binding protein FUS isoform X1

    Conserved Domains (2) summary
    cd12535
    Location:71 → 156
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:211 → 237
    zf-RanBP; Zn-finger in Ran binding protein and others
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56959.1 GenPept UniProtKB/Swiss-Prot:P56959

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