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LARP1 La ribonucleoprotein 1, translational regulator [ Homo sapiens (human) ]

Gene ID: 23367, updated on 28-Oct-2024

Summary

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Official Symbol
LARP1provided by HGNC
Official Full Name
La ribonucleoprotein 1, translational regulatorprovided by HGNC
Primary source
HGNC:HGNC:29531
See related
Ensembl:ENSG00000155506 MIM:612059; AllianceGenome:HGNC:29531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LARP; Lar1; Lhp1
Summary
Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Located in TORC1 complex and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues See more
Orthologs
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Genomic context

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See LARP1 in Genome Data Viewer
Location:
5q33.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (154682979..154817605)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (155216967..155351568)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154062539..154197165)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153962321-153962904 Neighboring gene CIR1P1-LARP1 intergenic CAGE-defined high expression enhancer Neighboring gene CIR1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153983238-153983756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:153983757-153984274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:153990742-153991511 Neighboring gene microRNA 3141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:154026765-154027427 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154070395-154071038 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:154076347-154076858 Neighboring gene microRNA 1303 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154091948-154092494 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83490 Neighboring gene RNA, 7SL, cytoplasmic 803, pseudogene Neighboring gene ribosomal protein L21 pseudogene 57 Neighboring gene uncharacterized LOC112267936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16553 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:154155175-154155753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:154161545-154162171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23487 Neighboring gene Sharpr-MPRA regulatory region 2591 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154236981-154237482 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:154237483-154237986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:154237987-154238489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:154238993-154239495 Neighboring gene CCR4-NOT transcription complex subunit 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder. Chettle J, et al. HGG Adv, 2024 Oct 10. PMID 39182167, Free PMC Article
  2. mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Jia JJ, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33398329, Free PMC Article
  3. LARP1 isoform expression in human cancer cell lines. Schwenzer H, et al. RNA Biol, 2021 Feb. PMID 32286153, Free PMC Article
  4. Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5' TOP motifs. Philippe L, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32094190, Free PMC Article
  5. The LARP1 La-Module recognizes both ends of TOP mRNAs. Al-Ashtal HA, et al. RNA Biol, 2021 Feb. PMID 31601159, Free PMC Article

See all (249) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder.
    Title: LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder.
  2. LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
    Title: LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
  3. Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1.
    Title: Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1.
  4. Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry.
    Title: Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry.
  5. [1]H, [13]C, and [15]N resonance assignments of the La Motif of the human La-related protein 1.
    Title: (1)H, (13)C, and (15)N resonance assignments of the La Motif of the human La-related protein 1.
  6. O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/beta-catenin signalling.
    Title: O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling.
  7. Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
    Title: Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
  8. Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.
    Title: Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.
  9. LARP1 isoform expression in human cancer cell lines.
    Title: LARP1 isoform expression in human cancer cell lines.
  10. The LARP1 La-Module recognizes both ends of TOP mRNAs.
    Title: The LARP1 La-Module recognizes both ends of TOP mRNAs.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated La ribonucleoprotein domain family, member 1 (LARP1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with La ribonucleoprotein domain family, member 1 (LARP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0731, MGC19556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables eukaryotic initiation factor 4E binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to rapamycin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
la-related protein 1
Names
La ribonucleoprotein domain family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367713.1 → NP_001354642.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
    Consensus CDS
    CCDS93807.1
    UniProtKB/TrEMBL
    A0A8I5KWU3
    Related
    ENSP00000509794.1, ENST00000685946.1

  2. NM_001367714.1 → NP_001354643.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
    Consensus CDS
    CCDS93807.1
    UniProtKB/TrEMBL
    A0A8I5KWU3
    Related
    ENSP00000508743.1, ENST00000690816.1

  3. NM_001367715.1 → NP_001354644.1  la-related protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169

  4. NM_001367716.1 → NP_001354645.1  la-related protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
    Consensus CDS
    CCDS93806.1
    UniProtKB/TrEMBL
    A0A8I5KSP1
    Related
    ENSP00000508958.1, ENST00000687700.1

  5. NM_001367717.1 → NP_001354646.1  la-related protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169

  6. NM_001367718.1 → NP_001354647.1  la-related protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC112169

  7. NM_001367719.1 → NP_001354648.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112169
    Consensus CDS
    CCDS93807.1
    UniProtKB/TrEMBL
    A0A8I5KWU3

  8. NM_015315.6 → NP_056130.2  la-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056130.2

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
    Consensus CDS
    CCDS4328.1
    UniProtKB/Swiss-Prot
    Q6PKG0
    Related
    ENSP00000336721.4, ENST00000336314.9
    Conserved Domains (4) summary
    smart00684
    Location:849 → 887
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:327 → 399
    LARP_1; La RNA-binding domain of La-related protein 1
    cl25751
    Location:123 → 535
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:11 → 251
    Atrophin-1; Atrophin-1 family

  9. NM_033551.3 → NP_291029.2  la-related protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112169
    UniProtKB/Swiss-Prot
    O94836, Q6PKG0, Q8N4M2, Q8NB73, Q9UFD7
    Related
    ENSP00000428589.2, ENST00000518297.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    154682979..154817605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417041.1 → XP_047272997.1  la-related protein 1 isoform X3

  2. XM_047417045.1 → XP_047273001.1  la-related protein 1 isoform X9

  3. XM_047417040.1 → XP_047272996.1  la-related protein 1 isoform X3

  4. XM_047417042.1 → XP_047272998.1  la-related protein 1 isoform X4

  5. XM_047417044.1 → XP_047273000.1  la-related protein 1 isoform X7

  6. XM_047417043.1 → XP_047272999.1  la-related protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KSP1

  7. XM_011537614.2 → XP_011535916.1  la-related protein 1 isoform X1

    Conserved Domains (3) summary
    smart00684
    Location:900 → 938
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:378 → 450
    LARP_1; La RNA-binding domain of La-related protein 1
    COG5193
    Location:177 → 529
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]

  8. XM_011537615.2 → XP_011535917.1  la-related protein 1 isoform X2

    Conserved Domains (3) summary
    smart00684
    Location:859 → 897
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:337 → 409
    LARP_1; La RNA-binding domain of La-related protein 1
    COG5193
    Location:211 → 488
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]

  9. XM_005268408.4 → XP_005268465.1  la-related protein 1 isoform X8

    See identical proteins and their annotated locations for XP_005268465.1

    UniProtKB/TrEMBL
    A0A8I5KWU3
    Conserved Domains (2) summary
    smart00684
    Location:721 → 759
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:199 → 271
    LARP_1; La RNA-binding domain of La-related protein 1

  10. XM_011537617.2 → XP_011535919.1  la-related protein 1 isoform X5

    Conserved Domains (2) summary
    smart00684
    Location:791 → 829
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:269 → 341
    LARP_1; La RNA-binding domain of La-related protein 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    155216967..155351568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352239.1 → XP_054208214.1  la-related protein 1 isoform X3

  2. XM_054352244.1 → XP_054208219.1  la-related protein 1 isoform X9

  3. XM_054352238.1 → XP_054208213.1  la-related protein 1 isoform X3

  4. XM_054352240.1 → XP_054208215.1  la-related protein 1 isoform X4

  5. XM_054352243.1 → XP_054208218.1  la-related protein 1 isoform X7

  6. XM_054352242.1 → XP_054208217.1  la-related protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KSP1

  7. XM_054352236.1 → XP_054208211.1  la-related protein 1 isoform X1

  8. XM_054352237.1 → XP_054208212.1  la-related protein 1 isoform X2

  9. XM_054352241.1 → XP_054208216.1  la-related protein 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PKG0.2 GenPept UniProtKB/Swiss-Prot:Q6PKG0

Gene LinkOut

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