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SUN1 Sad1 and UNC84 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 23353, updated on 14-Nov-2024

Summary

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Official Symbol
SUN1provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18587
See related
Ensembl:ENSG00000164828 MIM:607723; AllianceGenome:HGNC:18587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC84A
Summary
This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]
Expression
Ubiquitous expression in endometrium (RPKM 45.0), skin (RPKM 41.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SUN1 in Genome Data Viewer
Location:
7p22.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (815557..874934)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (918630..978053)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (855194..914571)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:770503-771002 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:791462-792661 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:821444-822643 Neighboring gene uncharacterized LOC124901567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:837226-837726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:849762-850262 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:850239-850399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:852706-853270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:853271-853834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:855273-856014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17821 Neighboring gene Sharpr-MPRA regulatory region 7003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:869831-870726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25474 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:871666-872865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25475 Neighboring gene uncharacterized LOC124901568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:923699-924455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:925261-925974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:925975-926688 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100798 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:932665-932864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:938411-938998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:938999-939585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:947339-948037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17826 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:967671-968257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25481 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17828 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:984861-986060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:988546-989191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:989192-989836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:992766-993377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17830 Neighboring gene uncharacterized LOC124901569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:994600-995209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Nuclear envelope localization of human UNC84A does not require nuclear lamins. Hasan S, et al. FEBS Lett, 2006 Feb 20. PMID 16445915
  2. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. Luo X, et al. J Virol, 2018 Jul 1. PMID 29643244, Free PMC Article
  3. Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. Chang W, et al. Proc Natl Acad Sci U S A, 2019 Feb 26. PMID 30808750, Free PMC Article
  4. Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. Patel JT, et al. Nucleus, 2014 Sep-Oct. PMID 25482198, Free PMC Article
  5. Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope. Jahed Z, et al. Biophys J, 2018 Mar 13. PMID 29539404, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUN1 inhibits osteogenesis and promotes adipogenesis of human adipose-derived stem cells by regulating alpha-tubulin and CD36 expression.
    Title: SUN1 inhibits osteogenesis and promotes adipogenesis of human adipose-derived stem cells by regulating α-tubulin and CD36 expression.
  2. SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
    Title: SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
  3. Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.
    Title: Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.
  4. Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.
    Title: Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.
  5. Nuclear restriction of HIV-1 infection by SUN1.
    Title: Nuclear restriction of HIV-1 infection by SUN1.
  6. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
  7. The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure.
    Title: The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure.
  8. The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
    Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
  9. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
  10. Progerin overexpression increased levels of SUN1, which couples the nucleus to microtubules through nesprin-2G and dynein, and microtubule association with the nucleus. Reducing microtubule-nuclear connections through SUN1 depletion or dynein inhibition rescued the polarity defects.
    Title: Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with Sad1 and UNC84 domain containing 1 (SUN1; UNC84A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: GET4

Homology

Clone Names

  • FLJ12407, KIAA0810, MGC176649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lamin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic attachment of telomere to nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear matrix anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
Inferred from Electronic Annotation
more info
  
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
SUN domain-containing protein 1
Names
Sad1 unc-84 domain protein 1
protein unc-84 homolog A
sad1/unc-84 protein-like 1
unc-84 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130965.3 → NP_001124437.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 72, and 73 all encode the same isoform (a).
    Source sequence(s)
    AB018353, AC099731, AK022816, BM689998
    Consensus CDS
    CCDS47525.1
    UniProtKB/Swiss-Prot
    A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
    UniProtKB/TrEMBL
    A7MCZ7
    Related
    ENSP00000384015.1, ENST00000401592.6
    Conserved Domains (5) summary
    COG1196
    Location:366 → 560
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:648 → 783
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:62 → 291
    MRP; Mitochondrial RNA binding protein MRP
    pfam18580
    Location:547 → 605
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21439
    Location:417 → 470
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  2. NM_001171944.2 → NP_001165415.1  SUN domain-containing protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks three in-frame exons in the middle portion of the coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55080.1
    UniProtKB/TrEMBL
    A0A8I5G938, A7MCZ7
    Related
    ENSP00000413439.2, ENST00000452783.6
    Conserved Domains (3) summary
    pfam07738
    Location:545 → 680
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:72 → 189
    MRP; Mitochondrial RNA binding protein MRP
    pfam16043
    Location:336 → 452
    DUF4795; Domain of unknown function (DUF4795)

  3. NM_001171945.2 → NP_001165416.1  SUN domain-containing protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate, upstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55078.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000395952.2, ENST00000457378.6
    Conserved Domains (1) summary
    pfam09387
    Location:93 → 269
    MRP; Mitochondrial RNA binding protein MRP

  4. NM_001171946.2 → NP_001165417.1  SUN domain-containing protein 1 isoform e

    See identical proteins and their annotated locations for NP_001165417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55079.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000383947.1, ENST00000403868.5
    Conserved Domains (1) summary
    pfam09387
    Location:72 → 248
    MRP; Mitochondrial RNA binding protein MRP

  5. NM_001367633.1 → NP_001354562.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (73), as well as variants 1 and 72, encodes isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS47525.1
    UniProtKB/Swiss-Prot
    A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
    UniProtKB/TrEMBL
    A7MCZ7
    Conserved Domains (5) summary
    COG1196
    Location:366 → 560
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:648 → 783
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:62 → 291
    MRP; Mitochondrial RNA binding protein MRP
    pfam18580
    Location:547 → 605
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21439
    Location:417 → 470
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  6. NM_001367634.1 → NP_001354563.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (72), as well as variants 1 and 73, encodes isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS47525.1
    UniProtKB/Swiss-Prot
    A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
    UniProtKB/TrEMBL
    A7MCZ7
    Conserved Domains (5) summary
    COG1196
    Location:366 → 560
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:648 → 783
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:62 → 291
    MRP; Mitochondrial RNA binding protein MRP
    pfam18580
    Location:547 → 605
    Sun2_CC2; SUN2 coiled coil domain 2
    cd21439
    Location:417 → 470
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  7. NM_001367635.1 → NP_001354564.1  SUN domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    H0Y6N5

  8. NM_001367636.1 → NP_001354565.1  SUN domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  9. NM_001367637.1 → NP_001354566.1  SUN domain-containing protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC099731

  10. NM_001367638.1 → NP_001354567.1  SUN domain-containing protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  11. NM_001367639.1 → NP_001354568.1  SUN domain-containing protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    H0Y6N5
    Related
    ENSP00000406653.1, ENST00000433212.5

  12. NM_001367640.1 → NP_001354569.1  SUN domain-containing protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  13. NM_001367641.1 → NP_001354570.1  SUN domain-containing protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  14. NM_001367642.1 → NP_001354571.1  SUN domain-containing protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  15. NM_001367643.1 → NP_001354572.1  SUN domain-containing protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  16. NM_001367644.1 → NP_001354573.1  SUN domain-containing protein 1 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  17. NM_001367645.1 → NP_001354574.1  SUN domain-containing protein 1 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  18. NM_001367646.1 → NP_001354575.1  SUN domain-containing protein 1 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    H0Y742

  19. NM_001367647.1 → NP_001354576.1  SUN domain-containing protein 1 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  20. NM_001367648.1 → NP_001354577.1  SUN domain-containing protein 1 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  21. NM_001367649.1 → NP_001354578.1  SUN domain-containing protein 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  22. NM_001367651.1 → NP_001354580.1  SUN domain-containing protein 1 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  23. NM_001367653.1 → NP_001354582.1  SUN domain-containing protein 1 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  24. NM_001367655.1 → NP_001354584.1  SUN domain-containing protein 1 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  25. NM_001367658.1 → NP_001354587.1  SUN domain-containing protein 1 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC099731

  26. NM_001367660.1 → NP_001354589.1  SUN domain-containing protein 1 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  27. NM_001367662.1 → NP_001354591.1  SUN domain-containing protein 1 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  28. NM_001367664.1 → NP_001354593.1  SUN domain-containing protein 1 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS94043.1
    UniProtKB/TrEMBL
    A7MCZ7, E9PHI4
    Related
    ENSP00000384116.1, ENST00000405266.5

  29. NM_001367665.1 → NP_001354594.1  SUN domain-containing protein 1 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  30. NM_001367666.1 → NP_001354595.1  SUN domain-containing protein 1 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  31. NM_001367667.1 → NP_001354596.1  SUN domain-containing protein 1 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  32. NM_001367668.1 → NP_001354597.1  SUN domain-containing protein 1 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  33. NM_001367669.1 → NP_001354598.1  SUN domain-containing protein 1 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  34. NM_001367670.1 → NP_001354599.1  SUN domain-containing protein 1 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  35. NM_001367671.1 → NP_001354600.1  SUN domain-containing protein 1 isoform hh

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  36. NM_001367672.1 → NP_001354601.1  SUN domain-containing protein 1 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  37. NM_001367673.1 → NP_001354602.1  SUN domain-containing protein 1 isoform jj

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    H0Y742
    Related
    ENSP00000409909.1, ENST00000429178.5

  38. NM_001367674.1 → NP_001354603.1  SUN domain-containing protein 1 isoform kk

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  39. NM_001367675.1 → NP_001354604.1  SUN domain-containing protein 1 isoform ll

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  40. NM_001367676.1 → NP_001354605.1  SUN domain-containing protein 1 isoform mm

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  41. NM_001367677.1 → NP_001354606.1  SUN domain-containing protein 1 isoform nn

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  42. NM_001367678.1 → NP_001354607.1  SUN domain-containing protein 1 isoform oo

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  43. NM_001367679.1 → NP_001354608.1  SUN domain-containing protein 1 isoform pp

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  44. NM_001367680.1 → NP_001354609.1  SUN domain-containing protein 1 isoform qq

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  45. NM_001367681.1 → NP_001354610.1  SUN domain-containing protein 1 isoform rr

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  46. NM_001367682.1 → NP_001354611.1  SUN domain-containing protein 1 isoform ss

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  47. NM_001367683.1 → NP_001354612.1  SUN domain-containing protein 1 isoform tt

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  48. NM_001367684.1 → NP_001354613.1  SUN domain-containing protein 1 isoform uu

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  49. NM_001367685.1 → NP_001354614.1  SUN domain-containing protein 1 isoform vv

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  50. NM_001367686.1 → NP_001354615.1  SUN domain-containing protein 1 isoform ww

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  51. NM_001367687.1 → NP_001354616.1  SUN domain-containing protein 1 isoform xx

    Status: REVIEWED

    Source sequence(s)
    AC099731

  52. NM_001367688.1 → NP_001354617.1  SUN domain-containing protein 1 isoform yy

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  53. NM_001367689.1 → NP_001354618.1  SUN domain-containing protein 1 isoform zz

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  54. NM_001367690.1 → NP_001354619.1  SUN domain-containing protein 1 isoform aaa

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  55. NM_001367691.1 → NP_001354620.1  SUN domain-containing protein 1 isoform bbb

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  56. NM_001367692.1 → NP_001354621.1  SUN domain-containing protein 1 isoform ccc

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A0A146IHP0, A7MCZ7

  57. NM_001367693.1 → NP_001354622.1  SUN domain-containing protein 1 isoform ddd

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  58. NM_001367694.1 → NP_001354623.1  SUN domain-containing protein 1 isoform eee

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  59. NM_001367695.1 → NP_001354624.1  SUN domain-containing protein 1 isoform fff

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  60. NM_001367696.1 → NP_001354625.1  SUN domain-containing protein 1 isoform ggg

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  61. NM_001367697.1 → NP_001354626.1  SUN domain-containing protein 1 isoform hhh

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  62. NM_001367698.1 → NP_001354627.1  SUN domain-containing protein 1 isoform iii

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  63. NM_001367699.1 → NP_001354628.1  SUN domain-containing protein 1 isoform jjj

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  64. NM_001367700.1 → NP_001354629.1  SUN domain-containing protein 1 isoform kkk

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  65. NM_001367701.1 → NP_001354630.1  SUN domain-containing protein 1 isoform lll

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  66. NM_001367702.1 → NP_001354631.1  SUN domain-containing protein 1 isoform mmm

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  67. NM_001367703.1 → NP_001354632.1  SUN domain-containing protein 1 isoform nnn

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  68. NM_001367704.1 → NP_001354633.1  SUN domain-containing protein 1 isoform ooo

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A7MCZ7

  69. NM_001367705.1 → NP_001354634.1  SUN domain-containing protein 1 isoform ppp

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0
    Related
    ENST00000413171.6

  70. NM_001367706.1 → NP_001354635.1  SUN domain-containing protein 1 isoform qqq

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    A4D2Q0

  71. NM_001367708.1 → NP_001354637.1  SUN domain-containing protein 1 isoform sss

    Status: REVIEWED

    Source sequence(s)
    AC099731
    UniProtKB/TrEMBL
    H0Y6N5

  72. NM_025154.6 → NP_079430.3  SUN domain-containing protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon in the 5' portion of the coding region. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS43533.1
    UniProtKB/TrEMBL
    A7MCZ7
    Related
    ENSP00000374225.3, ENST00000389574.7
    Conserved Domains (3) summary
    pfam07738
    Location:565 → 700
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:22 → 208
    MRP; Mitochondrial RNA binding protein MRP
    pfam16043
    Location:356 → 472
    DUF4795; Domain of unknown function (DUF4795)

RNA

  1. NR_160281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731

  2. NR_160282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731

  3. NR_160283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    815557..874934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    918630..978053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94901.4 GenPept UniProtKB/Swiss-Prot:O94901

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Tools
Miscellaneous