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TRIM2 tripartite motif containing 2 [ Homo sapiens (human) ]

Gene ID: 23321, updated on 14-Nov-2024

Summary

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Official Symbol
TRIM2provided by HGNC
Official Full Name
tripartite motif containing 2provided by HGNC
Primary source
HGNC:HGNC:15974
See related
Ensembl:ENSG00000109654 MIM:614141; AllianceGenome:HGNC:15974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT2R; RNF86
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRIM2 in Genome Data Viewer
Location:
4q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153152163..153339317)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156476134..156663746)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154073315..154260469)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15754 Neighboring gene Sharpr-MPRA regulatory region 8192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153877563-153878382 Neighboring gene uncharacterized LOC729870 Neighboring gene family with sequence similarity 192, member A pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:153892920-153894119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894208-153894728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153894729-153895248 Neighboring gene FH2 domain containing 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:153912200-153913399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:153913429-153913928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153942327-153943122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:153944769-153945310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:153949611-153950259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154028483-154028983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154033423-154033922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154057659-154058160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15755 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154127146-154128051 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154130352-154131177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154143059-154143560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154159939-154160440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154160441-154160940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154162218-154162718 Neighboring gene uncharacterized LOC105377496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154178381-154179026 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:154180767-154181283 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene transmembrane 131 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2. Guan X, et al. Acta Crystallogr F Struct Biol Commun, 2014 May. PMID 24817735, Free PMC Article
  2. TRIM2 is a novel promoter of human colorectal cancer. Cao H, et al. Scand J Gastroenterol, 2019 Feb. PMID 30916596
  3. TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma. Qin Y, et al. Int J Oncol, 2018 Oct. PMID 30066883
  4. Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis. Sun Q, et al. Oncogene, 2020 Oct. PMID 32929153
  5. Gene expression-phenotype associations in adults with eosinophilic esophagitis. Dellon ES, et al. Dig Liver Dis, 2018 Aug. PMID 29628359, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
    Title: Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
  2. Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
    Title: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
  3. Expression and Role of TRIM2 in Human Diseases.
    Title: Expression and Role of TRIM2 in Human Diseases.
  4. Knockdown of long noncoding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA3693p/TRIM2 axis.
    Title: Knockdown of long non‑coding RNA DLEU2 suppresses idiopathic pulmonary fibrosis by regulating the microRNA‑369‑3p/TRIM2 axis.
  5. Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.
    Title: Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis.
  6. Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
    Title: Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
  7. TRIM2 expression was significantly higher in colorectal cancer tissues than in non-cancerous tissues and was significantly associated with some clinicopathological factors. The results indicate that TRIM2 is a novel promoter of human colorectal cancer.
    Title: TRIM2 is a novel promoter of human colorectal cancer.
  8. TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
    Title: TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.
  9. Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma.
    Title: TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma.
  10. TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis.
    Title: Gene expression-phenotype associations in adults with eosinophilic esophagitis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Charcot-Marie-Tooth disease type 2R
MedGen: C3809655 OMIM: 615490 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study of severity in multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of tripartite motif containing 2 (TRIM2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 2
Names
Charcot-Marie-Tooth disease, type 2R
E3 ubiquitin-protein ligase TRIM2
RING finger protein 86
RING-type E3 ubiquitin transferase TRIM2
tripartite motif protein TRIM2
NP_001123539.1
NP_001289621.1
NP_001289622.1
NP_001289623.1
NP_001337983.1
NP_001337984.1
NP_001337985.1
NP_001337986.1
NP_001362417.1
NP_001362418.1
NP_001362419.1
NP_001362420.1
NP_001362441.1
NP_001362442.1
NP_001362443.1
NP_001362444.1
NP_001362445.1
NP_001362446.1
NP_001362448.1
NP_001362449.1
NP_001362451.1
NP_001362452.1
NP_001362454.1
NP_056086.2
XP_006714220.1
XP_006714221.1
XP_006714228.1
XP_011530098.1
XP_016863432.1
XP_016863437.1
XP_016863442.1
XP_047305905.1
XP_047305907.1
XP_047305908.1
XP_047305909.1
XP_047305910.1
XP_054205458.1
XP_054205459.1
XP_054205460.1
XP_054205461.1
XP_054205462.1
XP_054205463.1
XP_054205464.1
XP_054205465.1
XP_054205466.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041788.1 RefSeqGene

    Range
    56326..191200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130067.2 → NP_001123539.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001123539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate splice site, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011089, AC114791, AL110178, BC011052
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000415812.2, ENST00000437508.7
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  2. NM_001302692.2 → NP_001289621.1  tripartite motif-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AW071795, BC025417, DA631098
    UniProtKB/TrEMBL
    A0A0J9YW70, A0A0J9YXY2, C9JVI3
    Conserved Domains (1) summary
    cd00162
    Location:50 → 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. NM_001302693.2 → NP_001289622.1  tripartite motif-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC025417, DA407606, DA631098
    UniProtKB/TrEMBL
    A0A0J9YW70, A0A0J9YXY2, C9JVI3
    Conserved Domains (1) summary
    cd00162
    Location:49 → 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  4. NM_001302694.2 → NP_001289623.1  tripartite motif-containing protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 5' and 3' terminal exons and lacks several other 3' exons, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    BC025417, DA310963
    Consensus CDS
    CCDS93654.1
    UniProtKB/TrEMBL
    A0A0J9YW02, A0A0J9YW70, A0A0J9YXY2, C9JVI3
    Related
    ENSP00000487750.2, ENST00000482578.3
    Conserved Domains (1) summary
    cd00162
    Location:41 → 84
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  5. NM_001351054.2 → NP_001337983.1  tripartite motif-containing protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Consensus CDS
    CCDS93653.1
    UniProtKB/TrEMBL
    A0A6Q8PF74, A0A6Q8PFX3
    Related
    ENSP00000501672.1, ENST00000674935.1
    Conserved Domains (6) summary
    smart00502
    Location:179 → 305
    BBC; B-Box C-terminal domain
    smart00557
    Location:343 → 439
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:24 → 127
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:489 → 766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:38 → 83
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:133 → 174
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  6. NM_001351055.2 → NP_001337984.1  tripartite motif-containing protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Consensus CDS
    CCDS93655.1
    UniProtKB/TrEMBL
    A0A6Q8PFX3, A0A6Q8PGG4
    Related
    ENSP00000502266.1, ENST00000674726.1
    Conserved Domains (6) summary
    smart00502
    Location:178 → 304
    BBC; B-Box C-terminal domain
    smart00336
    Location:130 → 171
    BBOX; B-Box-type zinc finger
    smart00557
    Location:342 → 438
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:488 → 765
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:37 → 82
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:23 → 126
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  7. NM_001351056.2 → NP_001337985.1  tripartite motif-containing protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Consensus CDS
    CCDS93656.1
    UniProtKB/TrEMBL
    A0A6Q8PFX3, A0A6Q8PG16
    Related
    ENSP00000502077.1, ENST00000676408.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  8. NM_001351057.2 → NP_001337986.1  tripartite motif-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Conserved Domains (4) summary
    smart00502
    Location:36 → 162
    BBC; B-Box C-terminal domain
    smart00336
    Location:1 → 29
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200 → 296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346 → 619
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

  9. NM_001375488.1 → NP_001362417.1  tripartite motif-containing protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PEY7
    Related
    ENSP00000502083.1, ENST00000675673.1
    Conserved Domains (6) summary
    smart00502
    Location:219 → 345
    BBC; B-Box C-terminal domain
    smart00557
    Location:383 → 479
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:33 → 136
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:529 → 802
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:47 → 92
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl00034
    Location:142 → 214
    Bbox_SF; B-box-type zinc finger superfamily

  10. NM_001375489.1 → NP_001362418.1  tripartite motif-containing protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PEY7
    Related
    ENSP00000501562.1, ENST00000675063.1
    Conserved Domains (6) summary
    smart00502
    Location:218 → 344
    BBC; B-Box C-terminal domain
    smart00557
    Location:382 → 478
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:32 → 135
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:528 → 801
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:46 → 91
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl00034
    Location:141 → 213
    Bbox_SF; B-box-type zinc finger superfamily

  11. NM_001375490.1 → NP_001362419.1  tripartite motif-containing protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PGE9
    Related
    ENSP00000502541.1, ENST00000675780.1
    Conserved Domains (6) summary
    smart00502
    Location:188 → 295
    BBC; B-Box C-terminal domain
    smart00557
    Location:333 → 429
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:33 → 136
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:479 → 752
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:47 → 92
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:142 → 183
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  12. NM_001375491.1 → NP_001362420.1  tripartite motif-containing protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PGE9
    Related
    ENSP00000502290.1, ENST00000675340.1
    Conserved Domains (6) summary
    smart00502
    Location:187 → 294
    BBC; B-Box C-terminal domain
    smart00557
    Location:332 → 428
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:32 → 135
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:478 → 751
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:46 → 91
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:141 → 182
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  13. NM_001375512.1 → NP_001362441.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000502356.1, ENST00000674976.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  14. NM_001375513.1 → NP_001362442.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000502676.1, ENST00000675315.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  15. NM_001375514.1 → NP_001362443.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000501662.1, ENST00000675745.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  16. NM_001375515.1 → NP_001362444.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000501994.1, ENST00000676458.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  17. NM_001375516.1 → NP_001362445.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000502543.1, ENST00000675054.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  18. NM_001375517.1 → NP_001362446.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000501612.1, ENST00000676423.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  19. NM_001375519.1 → NP_001362448.1  tripartite motif-containing protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PF82
    Related
    ENSP00000502492.1, ENST00000675425.1
    Conserved Domains (4) summary
    smart00502
    Location:112 → 203
    BBC; B-Box C-terminal domain
    smart00557
    Location:241 → 337
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:387 → 660
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:42 → 92
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

  20. NM_001375520.1 → NP_001362449.1  tripartite motif-containing protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    UniProtKB/TrEMBL
    A0A6Q8PF82
    Related
    ENSP00000502720.1, ENST00000675492.1
    Conserved Domains (4) summary
    smart00502
    Location:111 → 202
    BBC; B-Box C-terminal domain
    smart00557
    Location:240 → 336
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:386 → 659
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:46 → 91
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

  21. NM_001375522.1 → NP_001362451.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS93657.1
    UniProtKB/TrEMBL
    A0A6Q8PFB0, A0A6Q8PHP4
    Related
    ENSP00000501997.1, ENST00000675710.1
    Conserved Domains (4) summary
    smart00502
    Location:75 → 201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239 → 335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385 → 658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:29 → 70
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  22. NM_001375523.1 → NP_001362452.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS93657.1
    UniProtKB/TrEMBL
    A0A6Q8PFB0, A0A6Q8PHP4
    Conserved Domains (4) summary
    smart00502
    Location:75 → 201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239 → 335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385 → 658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:29 → 70
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  23. NM_001375525.1 → NP_001362454.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Consensus CDS
    CCDS93657.1
    UniProtKB/TrEMBL
    A0A6Q8PFB0, A0A6Q8PHP4
    Related
    ENSP00000502776.1, ENST00000675782.1
    Conserved Domains (4) summary
    smart00502
    Location:75 → 201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239 → 335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385 → 658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:29 → 70
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  24. NM_015271.5 → NP_056086.2  tripartite motif-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056086.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF220018, AL110178, BC011052, DA631098
    Consensus CDS
    CCDS3781.2
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000339659.5, ENST00000338700.10
    Conserved Domains (7) summary
    smart00502
    Location:188 → 314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140 → 181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352 → 448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562 → 762
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:50 → 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498 → 771
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352 → 445
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    153152163..153339317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531796.4 → XP_011530098.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011530098.1

    UniProtKB/TrEMBL
    A0A6Q8PFX3, A0A6Q8PG16
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  2. XM_017007948.3 → XP_016863437.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1
    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Related
    ENSP00000502519.1, ENST00000674874.1
    Conserved Domains (6) summary
    smart00502
    Location:161 → 287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325 → 421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6 → 109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471 → 744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:20 → 65
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115 → 156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

  3. XM_047449953.1 → XP_047305909.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  4. XM_006714157.2 → XP_006714220.1  tripartite motif-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A6Q8PFX3
    Related
    ENST00000674718.1
    Conserved Domains (8) summary
    smart00502
    Location:188 → 314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140 → 181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352 → 448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562 → 766
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:50 → 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498 → 775
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352 → 445
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:519 → 554
    7WD40; WD40 repeat [structural motif]

  5. XM_006714158.2 → XP_006714221.1  tripartite motif-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A6Q8PFX3
    Related
    ENST00000675363.1
    Conserved Domains (8) summary
    smart00502
    Location:187 → 313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139 → 180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351 → 447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561 → 765
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:49 → 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497 → 774
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351 → 444
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:518 → 553
    7WD40; WD40 repeat [structural motif]

  6. XM_017007943.2 → XP_016863432.1  tripartite motif-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A6Q8PFB0
    Conserved Domains (7) summary
    smart00502
    Location:187 → 313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139 → 180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351 → 447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561 → 761
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:49 → 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497 → 770
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351 → 444
    Filamin; Filamin/ABP280 repeat

  7. XM_047449949.1 → XP_047305905.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16
    Related
    ENSP00000502775.1, ENST00000675899.1

  8. XM_047449952.1 → XP_047305908.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  9. XM_047449951.1 → XP_047305907.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  10. XM_047449954.1 → XP_047305910.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16
    Related
    ENSP00000502331.1, ENST00000676167.1

  11. XM_017007953.3 → XP_016863442.1  tripartite motif-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    C9J084
    Conserved Domains (4) summary
    smart00502
    Location:36 → 162
    BBC; B-Box C-terminal domain
    smart00557
    Location:200 → 296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346 → 623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cl00034
    Location:1 → 31
    Bbox_SF; B-box-type zinc finger superfamily

  12. XM_006714165.4 → XP_006714228.1  tripartite motif-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006714228.1

    UniProtKB/TrEMBL
    C9J084
    Conserved Domains (4) summary
    smart00502
    Location:36 → 162
    BBC; B-Box C-terminal domain
    smart00557
    Location:200 → 296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346 → 623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cl00034
    Location:1 → 31
    Bbox_SF; B-box-type zinc finger superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    156476134..156663746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349487.1 → XP_054205462.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  2. XM_054349489.1 → XP_054205464.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    D3DP09, O60272, Q9BSI9, Q9C040, Q9UFZ1

  3. XM_054349488.1 → XP_054205463.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  4. XM_054349483.1 → XP_054205458.1  tripartite motif-containing protein 2 isoform X1

  5. XM_054349484.1 → XP_054205459.1  tripartite motif-containing protein 2 isoform X2

  6. XM_054349485.1 → XP_054205460.1  tripartite motif-containing protein 2 isoform X3

  7. XM_054349486.1 → XP_054205461.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  8. XM_054349491.1 → XP_054205466.1  tripartite motif-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A6Q8PG16

  9. XM_054349490.1 → XP_054205465.1  tripartite motif-containing protein 2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C040.1 GenPept UniProtKB/Swiss-Prot:Q9C040

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