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HA hemagglutinin [ Influenza A virus (A/California/07/2009(H1N1)) ]

Gene ID: 23308115, updated on 18-Aug-2023

Summary

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Gene symbol
HA
Gene description
hemagglutinin
Locus tag
UJ99_s4gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/California/07/2009(H1N1)) (strain: A/California/07/2009, serotype: H1N1, nat-host: Homo sapiens; gender M; age 54)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus
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Genomic context

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Location:
segment: 4
Sequence:
NC_026433.1 (1..1701)

NC_026433.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_026433.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Change of phenotypic properties of escape mutants and readaptants of influenza virus A (H1N1)pdm09 under the influence of selected mutations in the molecule of hemagglutinin.]. Timofeeva TA, et al. Vopr Virusol, 2019. PMID 31412173
  2. [Evolution of pandemic influenza virus A(H1N1)pdm09 in 2009-2016: dynamics of receptor specificity of the first hemagglutinin subunit (HA1).]. Lvov DK, et al. Vopr Virusol, 2019. PMID 31412172
  3. Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium. Singanayagam A, et al. J Virol, 2019 Sep 1. PMID 31189708, Free PMC Article
  4. Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model. Nieto A, et al. Front Immunol, 2019. PMID 30787926, Free PMC Article
  5. The influenza virus hemagglutinin head evolves faster than the stalk domain. Kirkpatrick E, et al. Sci Rep, 2018 Jul 11. PMID 29992986, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phylogenetic analysis and clinical characteristics of the co-occurring mutations in HA and NA genes of influenza A(H1N1)pdm09 viruses during 2015-2017 in Beijing, China.
    Title: Phylogenetic analysis and clinical characteristics of the co-occurring mutations in HA and NA genes of influenza A(H1N1)pdm09 viruses during 2015-2017 in Beijing, China.
  2. Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
    Title: Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
  3. A comparative study of the antigenic specificity and receptor-binding activity of the escape mutants was conducted for the hemagglutinin of the influenza virus A/Moscow/01/2009 (H1N1)swl, and the readapted variants obtained for one of the escape mutants with reduced virulence.
    Title: [Change of phenotypic properties of escape mutants and readaptants of influenza virus A (H1N1)pdm09 under the influence of selected mutations in the molecule of hemagglutinin.].
  4. Evolution of pandemic influenza virus A(H1N1)pdm09 in 2009-2016: dynamics of receptor specificity of the first hemagglutinin subunit (HA1)
    Title: [Evolution of pandemic influenza virus A(H1N1)pdm09 in 2009-2016: dynamics of receptor specificity of the first hemagglutinin subunit (HA1).].
  5. Hemagglutinin cleavability, acid stability, and temperature dependence optimize influenza B virus for replication in human airways.
    Title: Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways.
  6. Data show that mutations that alter the HA pH of activation have marked effects on virus behavior and point toward an optimum pH of activation for influenza viruses to infect and replicate in humans.
    Title: Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium.
  7. this study shows that mutation S110L of H1N1 influenza virus hemagglutinin represents a potent determinant of attenuation in the mouse model
    Title: Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model.
  8. while the stalk domain does evolve over time, this evolution is slow and, historically, is not directed to aid in evading neutralizing antibody responses.
    Title: The influenza virus hemagglutinin head evolves faster than the stalk domain.
  9. substitutions in HA (Asp225Gly or Gln226Arg) and compensatory mutation decreasing the charge of HA (Lys123Asn, Lys157Asn, Gly158Glu, Asn159Asp, or Lys212Met) altered viral receptor-binding specificity and restored the functional balance between HA and NA; (2) Phe35Leu substitution in the PA protein increased viral polymerase activity.
    Title: [Mutations in Hemagglutinin and Polymerase Alter the Virulence of Pandemic A(H1N1) Influenza Virus].
  10. Data show that the messenger RNA (mRNA) levels of influenza A A virus viral HA and NS were significantly suppressed when newborn pig trachea (NPTr) cells overexpressed Sus scrofa microRNAs ssc-miR-204 and ssc-miR-4331.
    Title: Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively.
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Homology

General protein information

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Preferred Names
hemagglutinin
Names
HA1
HA2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_026433.1 Reference assembly

    Range
    1..1701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009118626.1 hemagglutinin [Influenza A virus (A/California/07/2009(H1N1))]

    See identical proteins and their annotated locations for YP_009118626.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    C3W627, M9QF95
    Conserved Domains (1) summary
    pfam00509
    Location:20 → 566
    Hemagglutinin; Haemagglutinin

  2. YP_009121768.1 HA1

    UniProtKB/TrEMBL
    D3THD7, D3THD9, D3THE5, D3THG0
    Conserved Domains (1) summary
    pfam00509
    Location:3 → 327
    Hemagglutinin; Haemagglutinin

  3. YP_009121767.1 HA2

    UniProtKB/TrEMBL
    A0A291FAF5
    Conserved Domains (1) summary
    pfam00509
    Location:1 → 222
    Hemagglutinin; Haemagglutinin
Nucleotide Protein
Heading Accession and Version

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