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KAZN kazrin, periplakin interacting protein [ Homo sapiens (human) ]

Gene ID: 23254, updated on 2-Nov-2024

Summary

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Official Symbol
KAZNprovided by HGNC
Official Full Name
kazrin, periplakin interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:29173
See related
Ensembl:ENSG00000189337 MIM:618301; AllianceGenome:HGNC:29173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAZ; C1orf196
Summary
This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]
Expression
Broad expression in spleen (RPKM 16.3), brain (RPKM 5.1) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See KAZN in Genome Data Viewer
Location:
1p36.21
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13892824..15118043)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (13334833..14562121)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (14925181..15444539)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 219 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14075835-14076053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 220 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14107388-14107556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14119276-14119776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14128246-14129019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14130567-14131339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14129793-14130566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:14170707-14171281 Neighboring gene PR/SET domain 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_267 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14273321-14273553 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_268 Neighboring gene MPRA-validated peak76 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:14462756-14463301 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:14462209-14462755 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:14493737-14494238 Neighboring gene RNA, U6 small nuclear 1265, pseudogene Neighboring gene uncharacterized LOC107985467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14585807-14586306 Neighboring gene uncharacterized LOC124903847 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:14672178-14673377 Neighboring gene MPRA-validated peak78 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:14696541-14697219 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:14699385-14700250 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:14730198-14731026 Neighboring gene KAZN antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14763664-14763765 Neighboring gene uncharacterized LOC124903850 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:14843423-14844622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:14898509-14899073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14955532-14956032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14956033-14956533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14964395-14964896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 227 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:15004649-15004813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15044353-15044920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15052062-15052748 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:15058961-15059682 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15059683-15060406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15058239-15058960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15061129-15061850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15061851-15062572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:15068552-15069136 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:15069137-15069720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15088664-15089164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15089165-15089665 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15105533-15106063 Neighboring gene uncharacterized LOC105376759 Neighboring gene tubulin folding cofactor A pseudogene 2 Neighboring gene uncharacterized LOC124903848 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:15148588-15149787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15152512-15153052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15162451-15162952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15175469-15175968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15194601-15195101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 229 Neighboring gene uncharacterized LOC107985469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15220320-15221320 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:15233506-15234705 Neighboring gene uncharacterized LOC124903849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15249981-15250480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 293 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:15261293-15261469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15266300-15266801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15270527-15271122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15273767-15274267 Neighboring gene Sharpr-MPRA regulatory region 2794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15296544-15297266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15294452-15295356 Neighboring gene Sharpr-MPRA regulatory region 10909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15347400-15348061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15348723-15349384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 230 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15379147-15379811 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15379812-15380475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15386302-15386802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15386803-15387303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:15390134-15391333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15427206-15427915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15438360-15438939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15438940-15439518 Neighboring gene TMEM51 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15481087-15481748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15480425-15481086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 296 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 299 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15513533-15514104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15514105-15514677 Neighboring gene TMEM51 antisense RNA 2 Neighboring gene transmembrane protein 51 Neighboring gene MFF pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KAZN as a diagnostic marker in ovarian cancer: a comprehensive analysis based on microarray, mRNA-sequencing, and methylation data. Zhu S, et al. BMC Cancer, 2022 Jun 16. PMID 35710397, Free PMC Article
  2. Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. Sevilla LM, et al. J Cell Sci, 2008 Nov 1. PMID 18840647
  3. Kazrin F is involved in apoptosis and interacts with BAX and ARC. Wang Q, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Sep. PMID 19727525
  4. KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. Nachat R, et al. J Cell Sci, 2009 Nov 15. PMID 19843585, Free PMC Article
  5. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. Groot KR, et al. J Cell Biol, 2004 Aug 30. PMID 15337775, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KAZN as a diagnostic marker in ovarian cancer: a comprehensive analysis based on microarray, mRNA-sequencing, and methylation data.
    Title: KAZN as a diagnostic marker in ovarian cancer: a comprehensive analysis based on microarray, mRNA-sequencing, and methylation data.
  2. exons 5-15 of kazrin, encoding the nuclear localization signal and C-terminal domain, are not required for epidermal development and function
    Title: Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis.
  3. kazrinE is a kazrin isoform with a liprin-homology domain(LHD), and associates with stabilised microtubules via its LHD. Overexpressed kazrinE in epidermal keratinocytes induces changes in cell shape and stimulates terminal differentiation.
    Title: KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. These results suggested that Kazrin F might play an important role in regulating cellular apoptosis by interacting with ARC and Bax.
    Title: Kazrin F is involved in apoptosis and interacts with BAX and ARC.
  6. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
  7. kazrin is a dual regulator of intercellular adhesion and differentiation in keratinocytes and regulates these processes by Rho-dependent and -independent mechanisms
    Title: Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation.
  8. Kazrin colocalizes with periplakin and desmoplakin at desmosomes and with periplakin at the interdesmosomal plasma membrane, but its subcellular distribution is independent of periplakin [kazrin]
    Title: Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10199, FLJ32593, FLJ43398, FLJ43806, KIAA1026, MGC126686, MGC142181, DKFZp686D08115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in desmosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
kazrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029844.2 RefSeqGene

    Range
    710300..1229658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017999.3 → NP_001017999.1  kazrin isoform C

    See identical proteins and their annotated locations for NP_001017999.1

    Status: REVIEWED

    Source sequence(s)
    AL035405, AL391215, AY505122
    Consensus CDS
    CCDS41268.1
    UniProtKB/Swiss-Prot
    Q674X7
    Related
    ENSP00000383601.3, ENST00000400797.3
    Conserved Domains (1) summary
    COG1196
    Location:3 → 150
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001018000.4 → NP_001018000.1  kazrin isoform B

    See identical proteins and their annotated locations for NP_001018000.1

    Status: REVIEWED

    Source sequence(s)
    AL035405, BC035501
    Consensus CDS
    CCDS30604.1
    UniProtKB/Swiss-Prot
    Q674X7
    Related
    ENSP00000354727.5, ENST00000361144.9
    Conserved Domains (2) summary
    pfam10473
    Location:72 → 195
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam13863
    Location:118 → 231
    DUF4200; Domain of unknown function (DUF4200)

  3. NM_001018001.3 → NP_001018001.1  kazrin isoform C

    See identical proteins and their annotated locations for NP_001018001.1

    Status: REVIEWED

    Source sequence(s)
    AL035405, AL391215, AY505121
    Consensus CDS
    CCDS41268.1
    UniProtKB/Swiss-Prot
    Q674X7
    Related
    ENSP00000383602.2, ENST00000400798.6
    Conserved Domains (1) summary
    COG1196
    Location:3 → 150
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_001370229.2 → NP_001357158.1  kazrin isoform F

    Status: REVIEWED

    Source sequence(s)
    AL035405, AL391215, AL445263
    Conserved Domains (1) summary
    TIGR02168
    Location:69 → 245
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001370230.2 → NP_001357159.1  kazrin isoform G

    Status: REVIEWED

    Source sequence(s)
    AL034395, AL035405, AL391215
    Conserved Domains (1) summary
    COG1196
    Location:21 → 179
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. NM_001370231.2 → NP_001357160.2  kazrin isoform C

    Status: REVIEWED

    Source sequence(s)
    AL035405, AL391215

  7. NM_015209.3 → NP_056024.1  kazrin isoform A

    See identical proteins and their annotated locations for NP_056024.1

    Status: REVIEWED

    Source sequence(s)
    AL034395, AL035405, AL391215
    Consensus CDS
    CCDS41267.1
    UniProtKB/Swiss-Prot
    Q674X7
    Conserved Domains (1) summary
    cl25732
    Location:78 → 254
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_201628.3 → NP_963922.2  kazrin isoform E

    See identical proteins and their annotated locations for NP_963922.2

    Status: REVIEWED

    Source sequence(s)
    AL034395, AL035405, AY505119, BI916330, BX648256, DA317442, DN831635, DR003677
    Consensus CDS
    CCDS152.2
    UniProtKB/Swiss-Prot
    B0QYQ0, B1AJZ1, B1AK78, Q5TGF1, Q674X4, Q674X6, Q674X7, Q6ZUD1, Q8IYN7, Q8N409, Q9UIL2, Q9UPX4
    UniProtKB/TrEMBL
    A0A1B0GWK2
    Related
    ENSP00000365198.2, ENST00000376030.7
    Conserved Domains (4) summary
    cd09564
    Location:443 → 512
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:522 → 586
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:608 → 679
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    cl25732
    Location:78 → 254
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    13892824..15118043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541074.4 → XP_011539376.1  kazrin isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWK2
    Conserved Domains (6) summary
    cd09564
    Location:541 → 610
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:620 → 684
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:706 → 777
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:541 → 608
    SAM; Sterile alpha motif
    pfam05010
    Location:175 → 350
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam13863
    Location:222 → 335
    DUF4200; Domain of unknown function (DUF4200)

  2. XM_005245795.6 → XP_005245852.1  kazrin isoform X4

    UniProtKB/TrEMBL
    A0A1B0GWK2
    Related
    ENSP00000490958.1, ENST00000636203.1
    Conserved Domains (6) summary
    cd09564
    Location:541 → 610
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:620 → 684
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:706 → 777
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:541 → 608
    SAM; Sterile alpha motif
    pfam05010
    Location:175 → 350
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam13863
    Location:222 → 335
    DUF4200; Domain of unknown function (DUF4200)

  3. XM_011541080.4 → XP_011539382.1  kazrin isoform X7

    Conserved Domains (4) summary
    cd09564
    Location:541 → 610
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    smart00454
    Location:541 → 608
    SAM; Sterile alpha motif
    pfam10473
    Location:176 → 299
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam13863
    Location:222 → 335
    DUF4200; Domain of unknown function (DUF4200)

  4. XM_017000770.3 → XP_016856259.1  kazrin isoform X11

  5. XM_017000768.3 → XP_016856257.1  kazrin isoform X9

  6. XM_017000769.3 → XP_016856258.1  kazrin isoform X10

  7. XM_047415845.1 → XP_047271801.1  kazrin isoform X2

  8. XM_017000771.2 → XP_016856260.1  kazrin isoform X12

    UniProtKB/Swiss-Prot
    Q674X7
    Related
    ENSP00000426015.1, ENST00000503743.5
    Conserved Domains (1) summary
    cl25732
    Location:78 → 254
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_047415858.1 → XP_047271814.1  kazrin isoform X5

  10. XM_011541075.3 → XP_011539377.1  kazrin isoform X3

    Conserved Domains (6) summary
    cd09564
    Location:437 → 506
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:516 → 580
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:602 → 673
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:437 → 504
    SAM; Sterile alpha motif
    pfam05010
    Location:71 → 246
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam13863
    Location:118 → 231
    DUF4200; Domain of unknown function (DUF4200)

  11. XM_047415880.1 → XP_047271836.1  kazrin isoform X13

  12. XM_011541077.3 → XP_011539379.1  kazrin isoform X6

    See identical proteins and their annotated locations for XP_011539379.1

    Conserved Domains (6) summary
    cd09564
    Location:349 → 418
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:428 → 492
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:514 → 585
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:349 → 416
    SAM; Sterile alpha motif
    pfam12718
    Location:31 → 150
    Tropomyosin_1; Tropomyosin like
    pfam13863
    Location:30 → 143
    DUF4200; Domain of unknown function (DUF4200)

  13. XM_011541076.3 → XP_011539378.1  kazrin isoform X6

    See identical proteins and their annotated locations for XP_011539378.1

    Conserved Domains (6) summary
    cd09564
    Location:349 → 418
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:428 → 492
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:514 → 585
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:349 → 416
    SAM; Sterile alpha motif
    pfam12718
    Location:31 → 150
    Tropomyosin_1; Tropomyosin like
    pfam13863
    Location:30 → 143
    DUF4200; Domain of unknown function (DUF4200)

  14. XM_047415868.1 → XP_047271824.1  kazrin isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    13334833..14562121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335402.1 → XP_054191377.1  kazrin isoform X14

  2. XM_054335404.1 → XP_054191379.1  kazrin isoform X4

  3. XM_054335408.1 → XP_054191383.1  kazrin isoform X7

  4. XM_054335412.1 → XP_054191387.1  kazrin isoform X11

  5. XM_054335410.1 → XP_054191385.1  kazrin isoform X9

  6. XM_054335411.1 → XP_054191386.1  kazrin isoform X10

  7. XM_054335413.1 → XP_054191388.1  kazrin isoform X12

  8. XM_054335405.1 → XP_054191380.1  kazrin isoform X16

  9. XM_054335403.1 → XP_054191378.1  kazrin isoform X15

  10. XM_054335414.1 → XP_054191389.1  kazrin isoform X13

  11. XM_054335406.1 → XP_054191381.1  kazrin isoform X17

  12. XM_054335407.1 → XP_054191382.1  kazrin isoform X17

  13. XM_054335409.1 → XP_054191384.1  kazrin isoform X18

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q674X7.2 GenPept UniProtKB/Swiss-Prot:Q674X7

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