FLT1 fms related receptor tyrosine kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FLT1provided by HGNC
Official Full Name: fms related receptor tyrosine kinase 1provided by HGNC
Primary source: HGNC:HGNC:3763
See related: Ensembl:ENSG00000102755 MIM:165070; AllianceGenome:HGNC:3763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLT; FLT-1; VEGFR1; VEGFR-1
Summary: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Expression: Biased expression in placenta (RPKM 90.6), thyroid (RPKM 20.1) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q12.3

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (28300346..28495128, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (27522576..27717351, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (28874483..29069265, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer.
Title: Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer.
FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer.
Title: FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer.
Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
Title: Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
Title: Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.
Title: Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
Title: A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
Title: Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.
Title: Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.
Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
Title: Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Title: SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.

Submit: New GeneRIF Correction See all GeneRIFs (726)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of a coronary artery disease risk variant. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates Flt-1 expression in human mesenchymal stem cells	PubMed
Nef	nef	HIV-1 Nef upregulates FLT1 in podocytes	PubMed
Tat	tat	HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF	PubMed
	tat	HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins	PubMed
	tat	The mechanism of monocyte activation by HIV-1 Tat involves the binding of Tat to VEGFR-1/Flt-1 and activating signals through this receptor	PubMed
	tat	The soluble form of VEGFR-1 inhibits monocyte polarization and migration induced by HIV-1 Tat	PubMed
	tat	The biologic activities of HIV-1 Tat in human monocytes are, at least in part, elicited by Tat activation of VEGFR-1/Flt-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S992 (e-PCR)
- UniSTS:152325

D13S1250 (e-PCR), detects polymorphism
- UniSTS:36869

A006Q11 (e-PCR)
- UniSTS:32774

RH44391 (e-PCR)
- UniSTS:14

D13S1448 (e-PCR)
- UniSTS:27665

D13S1715 (e-PCR)
- UniSTS:474388

RH119940 (e-PCR)
- UniSTS:133142

RH17924 (e-PCR)
- UniSTS:26403

GDB:218013 (e-PCR)
- UniSTS:156235

FLT1_2504 (e-PCR)
- UniSTS:280674

D13S666E (e-PCR)
- UniSTS:153198

FLT1-112 (e-PCR)
- UniSTS:55919

RH48311 (e-PCR)
- UniSTS:33413

RH122752 (e-PCR)
- UniSTS:134023

RH118501 (e-PCR)
- UniSTS:137896

RH65559 (e-PCR)
- UniSTS:39850

RH104153 (e-PCR)
- UniSTS:98478

GDB:180246 (e-PCR)
- UniSTS:155062

D13S1819 (e-PCR)
- UniSTS:29626

G60554 (e-PCR)
- UniSTS:137660

FLT1 (e-PCR)
- UniSTS:480193

RH47290 (e-PCR)
- UniSTS:2509

A006V36 (e-PCR)
- UniSTS:22240

RH104465 (e-PCR)
- UniSTS:98789

GDB:190836 (e-PCR)
- UniSTS:155626

RH70263 (e-PCR)
- UniSTS:83705

WI-7567 (e-PCR)
- UniSTS:70394

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hyaloid vascular plexus regression	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor receptor 1

Names: fms related tyrosine kinase 1; fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor

NP_001153392.1

EC 2.7.10.1

NP_001153502.1

EC 2.7.10.1

NP_001153503.1

EC 2.7.10.1

NP_002010.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012003.1 RefSeqGene

Range

5001..199783

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_425

mRNA and Protein(s)

NM_001159920.2 → NP_001153392.1 vascular endothelial growth factor receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001153392.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.

Source sequence(s)

AL138712, AL139005

Consensus CDS

CCDS73556.1

UniProtKB/TrEMBL

A0A1W2PNW4

Related

ENSP00000484039.1, ENST00000615840.5

Conserved Domains (5) summary

cd07702
Location:353 → 424

Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)

smart00409
Location:143 → 219

IG; Immunoglobulin

smart00410
Location:568 → 640

IG_like; Immunoglobulin like

pfam13927
Location:427 → 539

Ig_3; Immunoglobulin domain

cl11960
Location:245 → 327

Ig; Immunoglobulin domain
NM_001160030.2 → NP_001153502.1 vascular endothelial growth factor receptor 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001153502.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 3) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.

Source sequence(s)

AK300392, AL138712, EU360600, EU368830

Consensus CDS

CCDS53860.1

UniProtKB/TrEMBL

A0A1W2PNW4

Related

ENSP00000437631.1, ENST00000541932.5

Conserved Domains (5) summary

smart00410
Location:568 → 640

IG_like; Immunoglobulin like

cd00096
Location:248 → 252

Ig; Ig strand B [structural motif]

cd07702
Location:333 → 424

IgI_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1); member of the I-set of Ig superfamily (IgSF) domains

pfam13927
Location:427 → 539

Ig_3; Immunoglobulin domain

cl11960
Location:230 → 330

Ig; Immunoglobulin domain
NM_001160031.1 → NP_001153503.1 vascular endothelial growth factor receptor 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001153503.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 4) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.

Source sequence(s)

DA844548, EU826561

Consensus CDS

CCDS53861.1

UniProtKB/Swiss-Prot

P17948

Related

ENSP00000442630.1, ENST00000539099.2

Conserved Domains (4) summary

cd05742
Location:245 → 327

Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins

cd07702
Location:353 → 424

Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)

smart00410
Location:237 → 328

IG_like; Immunoglobulin like

cl11960
Location:439 → 466

Ig; Immunoglobulin domain
NM_002019.4 → NP_002010.2 vascular endothelial growth factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_002010.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) the longest isoform (1). Isoform 1 is a transmembrane protein.

Source sequence(s)

AF063657, AL138712, BU151621, BX504049, DA851664

Consensus CDS

CCDS9330.1

UniProtKB/Swiss-Prot

A3E342, A3E344, A8KA71, B0LPF1, B2BF46, B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, O60722, P16057, P17948, Q12954

UniProtKB/TrEMBL

L7RSL3

Related

ENSP00000282397.4, ENST00000282397.9

Conserved Domains (8) summary

cd05742
Location:245 → 327

Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins

cd07702
Location:353 → 424

Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)

smart00408
Location:676 → 738

IGc2; Immunoglobulin C-2 Type

smart00409
Location:568 → 640

IG; Immunoglobulin

smart00410
Location:237 → 328

IG_like; Immunoglobulin like

pfam07679
Location:661 → 748

I-set; Immunoglobulin I-set domain

cd14207
Location:819 → 1157

PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors

pfam07714
Location:827 → 1154

Pkinase_Tyr; Protein tyrosine kinase