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NACAD NAC alpha domain containing [ Homo sapiens (human) ]

Gene ID: 23148, updated on 2-Nov-2024

Summary

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Official Symbol
NACADprovided by HGNC
Official Full Name
NAC alpha domain containingprovided by HGNC
Primary source
HGNC:HGNC:22196
See related
Ensembl:ENSG00000136274 MIM:619419; AllianceGenome:HGNC:22196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 25.2), ovary (RPKM 5.5) and 11 other tissues See more
Orthologs
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Genomic context

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See NACAD in Genome Data Viewer
Location:
7p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (45080437..45088969, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45241246..45249778, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45120036..45128568, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45025394-45026140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45026141-45026888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45030540-45031094 Neighboring gene uncharacterized LOC102723334 Neighboring gene small nucleolar RNA host gene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25966 Neighboring gene small nucleolar RNA, H/ACA box 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18162 Neighboring gene CCM2 scaffold protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112087-45112746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:45112747-45113406 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99227 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:45143162-45143329 Neighboring gene transforming growth factor beta regulator 4 Neighboring gene small nucleolar RNA, H/ACA box 5A Neighboring gene small nucleolar RNA, H/ACA box 5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Nagase T, et al. DNA Res, 1997 Apr 28. PMID 9205841
  2. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
  3. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAC-alpha domain-containing protein 1
NP_001139806.1
XP_006715737.1
XP_054213645.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146334.2 → NP_001139806.1  NAC-alpha domain-containing protein 1

    See identical proteins and their annotated locations for NP_001139806.1

    Status: VALIDATED

    Source sequence(s)
    AB002361, AC013416, BM680676, BM728120, EG328798
    Consensus CDS
    CCDS47582.1
    UniProtKB/Swiss-Prot
    O15069
    Related
    ENSP00000420477.2, ENST00000490531.3
    Conserved Domains (3) summary
    COG1308
    Location:1415 → 1562
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14416
    Location:1519 → 1562
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    pfam01849
    Location:1416 → 1469
    NAC; NAC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    45080437..45088969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715674.4 → XP_006715737.1  NAC-alpha domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    COG1308
    Location:1202 → 1349
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14416
    Location:1306 → 1349
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    pfam01849
    Location:1203 → 1256
    NAC; NAC domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    45241246..45249778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357670.1 → XP_054213645.1  NAC-alpha domain-containing protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15069.3 GenPept UniProtKB/Swiss-Prot:O15069

Gene LinkOut

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